Bubuk Cinnamon burmani Menurunkan Kadar Glukosa Darah pada Tikus Putih Diabetik Diinduksi Alloxan

Giand Elmadahlia Tusara, Yoni Astuti

Abstract


Bubuk kayu manis mengandung flavonoid yang memiliki efek hipoglikemik untuk menurunkan kadar gula darah. Tujuan penelitian ini adalah untuk mengetahui efek pemberian bubuk kayu manis (Cinnamon burmani) terhadap kadar gula darah pada tikus diabetes diinduksi alloxan. Penelitian ini adalah penelitian eksperimental laboratorium dengan rancangan penelitian pre and post tets control design menggunakan 18 tikus yang dibagi menjadi 3 kelompok, masing-masing terdiri 6 ekor tikus. Kelompok pertama tidak diberikan perlakuan, kelompok kedua diberi bubuk C. burmani3,6 mg/hari dan kelompok ketiga diberi bubuk C. burmani7,2 mg/hari. Tikus di kelompok 2 dan 3 diberi bubuk C. burmani setiap hari selama 21 hari. Data yang diperoleh dianalisis menggunakan ANOVA satu jalan dilanjutkan dengan uji post-hoc Tukey HSD. Hasil uji menunjukkan bahwa pemberian bubuk C. burmani memberikan efek penurunan gula darah berrmakna (p< 0.05). Dosis terbaik untuk menurunkan kadar gula darah dalam penelitian ini adalah 7,2 mg/day setelah pemberian selama 21 hari. Pemberian dosis 2 kali lipat tidak menyebabkan kecepatan penurunan gula darah 2 kali lipat juga. Disimpulkan bahwa pemberian bubuk C. burmani dapat menurunkan kadar glukosa darah pada tikus putih diabetik yang diinduksi alloxan.

Cinnamon powder contain flavonoid as antioxidant and MHCP (methylhydroxy-chalcone poly­mer) which provide hypoglycemic effect to reduce level blood glucose. The aim of this study is to know the effect of cinnamon powder (Cinnamon burmani) given to the blood glucose in alloxan-induced dia­betic rats. This research was an experimental laboratory with pre and post tets control design using 18 rats were divided into three groups, each group were 6 rats. The first group were not given anything, the second group were given cinnamon powder 3,6 mg/day and the third were given cinnamon powder 7,2 mg/day. Rats in group 2 and 3 were given cinnamon powder everyday for 21 days. Hypoglycemic activity was evaluated at day 0, 7, 14 and 21. The data was compared statistically using one-way analysis of variance (ANOVA) followed by post-hoc test Tukey HSD. The result indicated that cinnamon powder giving significant effect on the reduction of blood glucose. In this research were used the optimum doses to decreasing blood glucose level at 7,2 mg/day after 21 days treatment The double doses cannot also decreasing speed of blood glucose causes. It was concluded that C. Burmani powder can decrease blood glucose levels in diabetic mice induced alloxan.


Keywords


Cinnamon burmani; gula darah; flavonoid; Diabetes Mellitus; Cinnamon burmani; blood glucose; flavonoid; Diabetes Mellitus

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