Gambaran Leukosit Pro Inflamasi pada Status Asmaticus di RSUD Kebumen

Ester Tri Rahayu, Adika Zhulhi Arjana, Juwariyah Juwariyah, Rahma Yuantari

Abstract


Asma merupakan kondisi penyempitan jalan nafas yang selama ini hanya dianggap sebagai reaksi hipersensitifitas tipe 1 karena pada kondisi lain juga dapat disebabkan oleh inflamasi dan koagulasi. Pada hipersensitifitas tipe 1 terdapat peran neutrofil dan eosinofil dan dalam penelitin ini akan dipetakan fenotip asma berdasarkan aktifitas eosinof dan neutrofil yaitu eosinofilik dan neutrofilik pada serangan akut asma. Penelitian dilakukan dengan desain observasional retrospektif  terhadap  data sekunder pasien asma dewasa, dalam waktu 1 tahun kebelakang dengan sampel sebanyak 91 orang di RSUD Kebumen. Pengambilan data menggunakan data rekam medis. Analisis data menggunakan uji ANOVA untuk data terdistribusi normal, dan uji rerata Kuskal-Wallis untuk data tidak normal. Karakteristik subyek sejumlah 91 orang, dengan 31 subyek pria dan rerata umur 38 tahun. Delapan puluh empat persen subjek adalah asma derajat ringan, 4 % berat dan sisanya sedang. Pada uji rerata eosinofil dan neutrofil, terdapat berbedaan rerata antar derajat serangan namun tidak signifikan secara statistik. Subyek asma neutrofilik lebih mendomasi dibandingkan eosinofilik. Walaupun begitu, belum dapat diambil kesimpulan hubungan kadar eosinofil dan neutrofil terhadap derajat asma karena belum ada hasil statistik yang signifikan.


Keywords


Eosinofil; Netrofil; Asma; Leukosit Pro Inflamasi

Full Text:

Download Article

References


Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Harrison’s Principles of Internal Medicine. 16th ed. The McGraw-Hill Companies; 2005.

Panek M, Mokros Ł, Pietras T, Kuna P. The Epidemiology of Asthma and Its Comorbidities in Poland – Health Problems of Patients with Severe Asthma as Evidenced in the Province of Lodz. Respir Med. 2016; 112:31–38.

Harkness LM, Ashton AW, Burgess JK. Asthma is Not Only an Airway Disease, but also a Vascular Disease. Pharmacol Ther, 2016;148: 17–33.

Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T. Th9 Cells Elicit Eosinophil-Independent Bronchial Hyperresponsiveness in Mice. Allergol Int. 2016; 65: 24–29.

Theml H, Diem H, Haferlach T. Color Atlas of Hematology. Thieme. 2004. 1-5.

Provan D. Oxford Handbook of Clinical Haematology. Medicine (Baltimore), 2009; 98 (6): 920-925.

Gorczynski R, Stanley J. Clinical Immunology. Clinical inmunology. 2013.

Cruse JM, Lewis RE. Illustrated dictionary of immunology. 2003.

Hoppenot D, Malakauskas K, Lavinskienė S, Bajoriūnienė I, Kalinauskaitė V, Sakalauskas R. Peripheral Blood Th9 Cells and Eosinophil Apoptosis in Asthma Patients. Medicina (B Aires). 2015; 51 (1): 10–17.

Lukawska JJ, Livieratos L, Sawyer BM, Lee T, O’Doherty M, Blower PJ, et al. Imaging Inflammation in Asthma: Real Time, Differential Tracking of Human Neutrophil and Eosinophil Migration in Allergen Challenged, Atopic Asthmatics in Vivo. EBioMedicine. 2014; 1 (2): 173–180.

Mazzeo C, Cañas JA, Zafra MP, Rojas Marco A, Fernández-Nieto M, Sanz V, et al. Exosome Secretion by Eosinophils: A Possible Role in Asthma Pathogenesis. J Allergy Clin Immunol, 2015; 135 (6): 1603–1613.

Athari SS, Athari SM. The Importance of Eosinophil, Platelet and Dendritic Cell in Asthma. Asian Pacific J Trop Dis, 2014; 4: S41–7.

Dworski R, Simon H-U, Hoskins A, Yousefi S. Eosinophil and Neutrophil Extracellular DNA Traps in Human Allergic Asthmatic Airways. J Allergy Clin Immunol, 2011 [cited 2016 Oct 5]; 127 (5): 1260–1266.

Global Initiative for Asthma. Pocket Guide for Asthma Management and Prevention. 2016.

McCallister JW, Holbrook JT, Wei CY, Parsons JP, Benninger CG, Dixon AE, et al. Sex Differences in Asthma Symptom Profiles and Control in the American Lung Association Asthma Clinical Research Centers. Respir Med [Internet]. 2013; 107 (10): 1491–1500.

Temprano J, Mannino DM. The Effect of Sex on Asthma Control from the National Asthma Survey. J Allergy Clin Immunol [Internet]. 2009; 123 (4): 854–860.

Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, et al. Effects of Older Age and Age of Asthma Onset on Clinical and Inflammatory Variables in Severe Refractory Asthma. Respir Med [Internet]. 2016; 118: 46–52.

Mehta AB, Hoffbrand AV. Haematology at a Glance. 2014.

Btech VV. Inhibition of Eosinophil Apoptosis by Asthma-Relevant Cytokines from Platelets. J Allergy Clin Immunol, 2015; 136 (4): 1134-1139.

Fahy J V. Eosinophilic and Neutrophilic Inflammation in Asthma: Insights from Clinical Studies. Proc Am Thorac Soc, 2009; 6 (3): 256–259.


Refbacks

  • There are currently no refbacks.




Office:
Faculty of Medicine and Health Science Universitas Muhammadiyah Yogyakarta,
Gedung G1 (Biomedik) Lantai Dasar, FKIK UMY, Phone: +62 274 387 656 (ext: 231)
Jalan Lingkar Selatan, Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta, Indonesia
Website: http://journal.umy.ac.id/index.php/mm - E-mail: jmmfkik@umy.ac.id

Creative Commons License
MMJKK is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.