Advancing Cardiovascular Risk Prediction: A Review of Machine Learning Models and Their Clinical Potential

Authors

  • Rona Regen Master Program of Electrical Engineering, Faculty of Industrial Technology, Universitas Islam Indonesia
  • Hendra Setiawan Master Program of Electrical Engineering, Faculty of Industrial Technology, Universitas Islam Indonesia

DOI:

https://doi.org/10.18196/jet.v8i2.25208

Keywords:

Machine Learning, Heart Disease Risk Prediction, Clinical Applications, Predictive Modeling, Early Detection

Abstract

This study conducts a systematic literature review on the application of machine learning technology in predicting heart disease risk. A total of 20 recent articles were identified and analyzed to evaluate the most used algorithms and their performance. The results show that Random Forest (RF), Logistic Regression (LR), Support Vector Machine (SVM), Decision Tree (DT), and K-Nearest Neighbors (KNN) are the most frequently applied models, with average accuracies of 89.56%, 83.14%, 83.14%, 82.57%, and 79.40%, respectively. In addition to comparing accuracy, this review also evaluates the strengths, weaknesses, and potential challenges of implementing each algorithm in clinical applications. The analysis reveals that Random Forest demonstrates high stability and accuracy, making it the leading candidate for large-scale clinical heart disease risk prediction applications. These findings are expected to provide new insights for the development of more accurate, reliable, and clinically deployable machine learning predictive models to support medical decision-making.

References

“Cardiovascular diseases (CVDs).” Accessed: Mar. 12, 2024. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

H. Wang, Q. Zu, J. Chen, Z. Yang, and M. A. Ahmed, “Application of Artificial Intelligence in Acute Coronary Syndrome: A Brief Literature Review,” Adv. Ther., vol. 38, no. 10, pp. 5078–5086, Oct. 2021, doi: 10.1007/s12325-021-01908-2.

M. P. Cote, J. H. Lubowitz, J. C. Brand, and M. J. Rossi, “Artificial intelligence, machine learning, and medicine: a little background goes a long way toward understanding,” Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 37, no. 6. Elsevier, pp. 1699–1702, 2021. Accessed: May 24, 2024. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0749806321003856

S. Dalal et al., “Application of Machine Learning for Cardiovascular Disease Risk Prediction,” Comput. Intell. Neurosci., vol. 2023, p. e9418666, Mar. 2023, doi: 10.1155/2023/9418666.

J.-J. Beunza et al., “Comparison of machine learning algorithms for clinical event prediction (risk of coronary heart disease),” J. Biomed. Inform., vol. 97, p. 103257, Sep. 2019, doi: 10.1016/j.jbi.2019.103257.

H. Shi et al., “Explainable machine learning model for predicting the occurrence of postoperative malnutrition in children with congenital heart disease,” Clin. Nutr., vol. 41, no. 1, pp. 202–210, Jan. 2022, doi: 10.1016/j.clnu.2021.11.006.

S. Matin Malakouti, “Heart disease classification based on ECG using machine learning models,” Biomed. Signal Process. Control, vol. 84, p. 104796, Jul. 2023, doi: 10.1016/j.bspc.2023.104796.

P. Singh, P. S. Kourav, S. Mohapatra, V. Kumar, and S. K. Panda, “Human heart health prediction using GAIT parameters and machine learning model,” Biomed. Signal Process. Control, vol. 88, p. 105696, Feb. 2024, doi: 10.1016/j.bspc.2023.105696.

G. Ramkumar, J. Seetha, R. Priyadarshini, M. Gopila, and G. Saranya, “IoT-based patient monitoring system for predicting heart disease using deep learning,” Measurement, vol. 218, p. 113235, Aug. 2023, doi: 10.1016/j.measurement.2023.113235.

Y. Huang et al., “Using a machine learning-based risk prediction model to analyze the coronary artery calcification score and predict coronary heart disease and risk assessment,” Comput. Biol. Med., vol. 151, p. 106297, Dec. 2022, doi: 10.1016/j.compbiomed.2022.106297.

S. Mohan, C. Thirumalai, and G. Srivastava, “Effective heart disease prediction using hybrid machine learning techniques,” IEEE Access, vol. 7, pp. 81542–81554, 2019.

N. L. Fitriyani, M. Syafrudin, G. Alfian, and J. Rhee, “HDPM: an effective heart disease prediction model for a clinical decision support system,” IEEE Access, vol. 8, pp. 133034–133050, 2020.

A. M. Qadri, A. Raza, K. Munir, and M. Almutairi, “Effective feature engineering technique for heart disease prediction with machine learning,” IEEE Access, 2023, Accessed: May 25, 2024. [Online]. Available: https://ieeexplore.ieee.org/abstract/document/10138551/

P. Ghosh et al., “Efficient prediction of cardiovascular disease using machine learning algorithms with relief and LASSO feature selection techniques,” IEEE Access, vol. 9, pp. 19304–19326, 2021.

S. E. Ashri, M. M. El-Gayar, and E. M. El-Daydamony, “HDPF: heart disease prediction framework based on hybrid classifiers and genetic algorithm,” Ieee Access, vol. 9, pp. 146797–146809, 2021.

K. M. Mohi Uddin, R. Ripa, N. Yeasmin, N. Biswas, and S. K. Dey, “Machine learning-based approach to the diagnosis of cardiovascular vascular disease using a combined dataset,” Intell.-Based Med., vol. 7, p. 100100, Jan. 2023, doi: 10.1016/j.ibmed.2023.100100.

M. N. Uddin and R. K. Halder, “An ensemble method based multilayer dynamic system to predict cardiovascular disease using machine learning approach,” Inform. Med. Unlocked, vol. 24, p. 100584, Jan. 2021, doi: 10.1016/j.imu.2021.100584.

M. S. Nawaz, B. Shoaib, and M. A. Ashraf, “Intelligent cardiovascular disease prediction empowered with gradient descent optimization,” Heliyon, vol. 7, no. 5, 2021, Accessed: May 25, 2024. [Online]. Available: https://www.cell.com/heliyon/pdf/S2405-8440(21)01051-3.pdf

J. P. Li, A. U. Haq, S. U. Din, J. Khan, A. Khan, and A. Saboor, “Heart disease identification method using machine learning classification in e-healthcare,” IEEE Access, vol. 8, pp. 107562–107582, 2020.

R. Rajendran and A. Karthi, “Heart disease prediction using entropy based feature engineering and ensembling of machine learning classifiers,” Expert Syst. Appl., vol. 207, p. 117882, Nov. 2022, doi: 10.1016/j.eswa.2022.117882.

P. Yang, H. Qiu, L. Wang, and L. Zhou, “Early prediction of high-cost inpatients with ischemic heart disease using network analytics and machine learning,” Expert Syst. Appl., vol. 210, p. 118541, Dec. 2022, doi: 10.1016/j.eswa.2022.118541.

E. Maini, B. Venkateswarlu, B. Maini, and D. Marwaha, “Machine learning–based heart disease prediction system for Indian population: An exploratory study done in South India,” Med. J. Armed Forces India, vol. 77, no. 3, pp. 302–311, Jul. 2021, doi: 10.1016/j.mjafi.2020.10.013.

Md. M. Ali et al., “A machine learning approach for risk factors analysis and survival prediction of Heart Failure patients,” Healthc. Anal., vol. 3, p. 100182, Nov. 2023, doi: 10.1016/j.health.2023.100182.

T. M. Mitchell and M. Learning, “Mcgraw-hill science,” Engineering/Math, vol. 1, p. 27, 1997.

L. Breiman, “RFs,” Mach. Learn., vol. 45, no. 1, pp. 5–32, Oct. 2001, doi: 10.1023/A:1010933404324.

D. W. Hosmer Jr, S. Lemeshow, and R. X. Sturdivant, Applied LR. John Wiley & Sons, 2013. Accessed: Dec. 12, 2024. [Online]. Available: https://books.google.com/books?hl=en&lr=&id=bRoxQBIZRd4C&oi=fnd&pg=PR13&dq=Hosmer,+D.+W.,+Lemeshow,+S.,+%26+Sturdivant,+R.+X.+(2013).+Applied+Logistic+Regression.+Wiley&ots=kM3Opu7Wd5&sig=9vZfiqVamRxGCuxdwB5uz8HwhoI

J. M. Moguerza and A. Muñoz, “SVM with applications,” 2006, Accessed: Dec. 12, 2024. [Online]. Available: https://projecteuclid.org/journals/statistical-science/volume-21/issue-3/Support-Vector-Machines-with-Applications/10.1214/088342306000000493.short

T. Cover and P. Hart, “Nearest neighbor pattern classification,” IEEE Trans. Inf. Theory, vol. 13, no. 1, pp. 21–27, 1967.

S. M. M. Hasan, M. A. Mamun, M. P. Uddin, and M. A. Hossain, “Comparative analysis of classification approaches for heart disease prediction,” in 2018 International Conference on Computer, Communication, Chemical, Material and Electronic Engineering (IC4ME2), IEEE, 2018, pp. 1–4. Accessed: May 25, 2024. [Online]. Available: https://ieeexplore.ieee.org/abstract/document/8465594/

M. M. Ali, B. K. Paul, K. Ahmed, F. M. Bui, J. M. W. Quinn, and M. A. Moni, “Heart disease prediction using supervised machine learning algorithms: Performance analysis and comparison,” Comput. Biol. Med., vol. 136, p. 104672, Sep. 2021, doi: 10.1016/j.compbiomed.2021.104672.

J. R. Quinlan, “Induction of DTs,” Mach. Learn., vol. 1, no. 1, pp. 81–106, Mar. 1986, doi: 10.1007/BF00116251.

S. Uddin, A. Khan, M. E. Hossain, and M. A. Moni, “Comparing different supervised machine learning algorithms for disease prediction,” BMC Med. Inform. Decis. Mak., vol. 19, no. 1, p. 281, Dec. 2019, doi: 10.1186/s12911-019-1004-8.

Downloads

Published

2025-04-21

How to Cite

Regen, R., & Setiawan, H. (2025). Advancing Cardiovascular Risk Prediction: A Review of Machine Learning Models and Their Clinical Potential. Journal of Electrical Technology UMY, 8(2), 51–59. https://doi.org/10.18196/jet.v8i2.25208

Issue

Section

Articles