Daya Antihelmintik Nanas (Ananas comocus) terhadap Ascaris lumbricoides secara In Vitro

Authors

  • Jeri Adli Fakultas Kedokteran Universitas Muhammadiyah Yogyakarta
  • Sri Sundari Bagian Parasitologi Fakultas Kedokteran Universitas Muhammadiyah Yogyakarta

DOI:

https://doi.org/10.18196/mmjkk.v8i2%20(s).1633

Keywords:

antihelmintik, Ascaris Lumbricoides, nanas (Ananas comocus), Antihelmintic, Ascaris lumbricoies, Ananas comocus, in vitro

Abstract

Ascariasis is one disease with high risk. In long time ago, Indonesian people was using traditional medicine from plant and animal, but nothing study to research it. The aim of this study is to determine the antihelmintic effect ofpineapple for Ascaris. The method of this study is experimental, the collected data with cohort. The sample is ascaris with same size, the gender is woman. The study using Pyrantel Pamoat, NaCl 0,9% and pineapple with any concentration.This research used 8 groups of experiment, they were 6 groups consisted of pineapple in 100%,75%,505,25%,10% and 5% and 2 groups of control used physiological salt and pirantel pamoat 0,236%. Result of this research showed that concentration of pineapple extract 100% there was non significant difference(P>0,05) within pirantel pamoat. Concentration ofpineapple extract 75%,50%,25%,10% and 5% had significant difference(P<0,05) with pirantel pamoat. Probhit analyze is got LD 50 pineapple extract (ananas comocus) is 20.50314% with the boundary gyration of under 13.83529 and boundary gyration to the 30.38451.LD 90 Pineapple extract is 81.05742 with the boundary gyration of under 40.94076 and boundary gyration to the 160.4833.While LD 95 from Pineapple extract is 119.6979 with the boundary gyration of under 52.37216 and boundary gyration to the 273.5727. In conclusion, Pineapple (Ananas comocus) have antihelminthic effect for Ascaris but the dose more better than Pyrantel Pamoat.

Ascariasis adalah salah satu penyakit dengan resiko tinggi. Sejas dahulu kala orang Indonesia memakai obat tradisional dari tanaman dan hewan tetapi belum ada penelitian yang mengkaji hal tersebut. Tujuan penelitian ini adalah untuk mengkaji efek antihenmintik buah nanas terhadap Ascaris lumbricoies. Desain penelitian adalah eksperimental dengan data dikoleksi secara cohort. Sampel adalah Ascaris dengan ukuran dan jenis kelamin sama yaitu betina. Penelitian dengan Pyrantel Pamoat, NaCl 0,9% dan buah nanas dalam beberapa konsentrasi. Ada 8 kelompok yaitu 6 kelompok buah nanas dengan konsentrasi 100%,75%,505,25%,10% dan 5%, serta 2 kelompok control dengan garam fisiologis dan pirantel pamoat 0,236%. Hasil penelitian menunjukkan bahwa buah nanas 100% tidak berbeda bermakna (p>0,05) dengan pirantel pamoat, buah nanas konsentrasi 75%,50%,25%,10% dan 5% berbeda bermakna (p<0,05) dengan pirantel pamoat. Hasil analisis Probit menunjukkan bahwa. Lethal Dosis 50 (LD 50) perasan nanas adalah 20.50314%. Lethal Dosis 90 (LD 90) perasan nanas adalah 81.05742%. Lethal Dosis 95 (LD 95) perasan nanas adalah 116.6979. Dapat disimpulkan bahwa perasan nanas (Ananas comocus) mempunyai daya antihelmintik terhadap Ascaris lumbricoides.

References

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Published

2016-05-31

Issue

Vol. 8 No. 2 (s) (2008): Oktober

Section

Research

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