Ekspresi Cyclooxygenase-2 dan angiogenesis pada kanker colorectal: Penelitian di Wuhan University, China
DOI:
https://doi.org/10.18196/mmjkk.v5i1.1866Abstract
Cyclooxygenase-2 (COX-2) penting pada berbagai fungsi seluler antara lain pertumbuhan dan deferensiasi sel, invasi sel kanker, angiogenesis dan fungsi imun. Angiogenesis sangat berperan pada perkembangan sel-sel kanker. Hubungan antara COX-2 sebagai faktor angiogenik pada kanker colorectal belum diketahui dengan jelas.Tujuan:
Penelitian ini bertujuan untuk menganalisis hubungan antara ekspresi COX-2 dalam kanker colorectal dengan vascular endothelial growth factor (VEGF) dan microvascular density (MVD).
Metode :
Ekspresi cyclooxygenase-2 ,VEGF dan MDV dianalisa dengan tehnikimunohistokimia pada 128 kasus kanker colorectal. Selanjutnya dilakukan analisis hubungan antara ekspresi COX-2 , ekspresi VEGF dan MVD.
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