The Correlation between Lymphocyte Platelet Ratio and Gensini Score in Coronary Heart Disease Patients
DOI:
https://doi.org/10.18196/mm.200136Keywords:
Coronary heart disease, Gensini score, Lymphocyte platelet ratioAbstract
The lymphocyte platelet ratio (LPR) is an inflammatory marker that can be used to identify the severity of coronary heart disease (CHD). This study aims to determine the correlation between the lymphocyte platelet ratio and Gensini scores in CHD patients. This research used correlative analytical research with a cross-sectional design. The sample was selected by consecutive sampling technique and obtained 51 respondents. The calculation of the LPR was carried out by dividing the number of platelets and lymphocytes in the volume unit of 103/mm3. Meanwhile, the Gensini score assessment was carried out by multiplying the percentage of blockages and location of blockages based on the result of coronary angiography. Based on the Gensini score, the sample in this study was classified as mild atherosclerosis with the Gensini score <25 points, and severe atherosclerosis with the Gensini score ≥25 points. The data were analyzed using the Pearson correlation test. The result showed that the average LPR value in samples with severe atherosclerosis was 124.6 and 115.3 in mild atherosclerosis. Based on the result of statistical analysis using the Pearson test, the p-value was 0.107. It can be concluded that there is no significant correlation between the lymphocyte platelet ratio and Gensini scores in CHD patients.
References
Mendis, S., Puska, P., Norrving, B., & World Health Organization. Global atlas on cardiovascular disease prevention and control. Geneva: World Health Organization. 2011.
Kemenkes, R. I. Infodatin: Situasi Kesehatan Jantung. Pusat Data dan Informasi Kementerian Kesehatan RI, 1-8. 2014.
Datta, S., Iqbal, Z., & Prasad, K. R. Comparison between serum hsCRP and LDL cholesterol for search of a better predictor for ischemic heart disease. Indian Journal of Clinical Biochemistry, 2011; 26 (2): 210-213.
Zhou, D., Wang, G., Fan, Y., Wan, Z., & Liu, X. Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of percutaneous coronary intervention in the Chinese Han population. Experimental and therapeutic medicine, 2017; 13 (2): 731-738.
Yüksel, M., Yıldız, A., Oylumlu, M., Akyüz, A., Aydın, M., Kaya, H., ... & Alan, S. The association between platelet/lymphocyte ratio and coronary artery disease severity. Anatolian journal of cardiology, 2016; 15 (8): 640.
Akboga, M. K., Canpolat, U., Yayla, C., Ozcan, F., Ozeke, O., Topaloglu, S., & Aras, D. Association of platelet to lymphocyte ratio with inflammation and severity of coronary atherosclerosis in patients with stable coronary artery disease. Angiology, 2016;
(1): 89-95.
Temiz, A., Gazi, E., Güngör, Ö., Barutçu, A., Altun, B., Bekler, A., ... & Gazi, S. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Medical science monitor: international medical journal of experimental and clinical research, 2014; 20: 660.
Li, H., Zhou, Y., Ma, Y., Han, S., & Zhou, L. The prognostic value of the platelet-to-lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis. Kardiologia Polska (Polish Heart Journal), 2017; 75 (7): 666-673.
Sari, I., Sunbul, M., Mammadov, C., Durmus, E., Bozbay, M., Kivrak, T., & Gerin, F. Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography. Kardiologia Polska (Polish Heart Journal), 2015;
(12): 1310-1316.
Irmalita, J. D., Andrianto, S. B., Tobing, D. P. L., Firman, D., & Firdaus, I. Pedoman tatalaksana sindrom koroner akut. ke-3. Indonesia: PERKI. 2015.
Efe, E., Kocayiğit, I., Türker, P. M., Murat, K., Erkan, A., Sedat, T., ... & Bahri, A. Platelet-to-lymphocyte ratio but not neutrophil-to-lymphocyte ratio predicts high on-treatment platelet reactivity in clopidogrel-treated patients with acute coronary syndrome. Indian journal of pharmacology, 2016;
(4): 355.
Bayrakci, N., Ozkayar, N., Akyel, F., Ates, I., Akyel, S., & Dede, F. The platelet-to-lymphocyte ratio as an inflammation marker in non-dipper hypertensive patients. Hippokratia, 2015; 19 (2): 114.
Mertoglu, C., & Gunay, M. Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017; 11: S127-S131.
Downloads
Published
Issue
Section
License
Copyright
Authors retain copyright and grant Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK) the right of first publication with the work simultaneously licensed under an Attribution 4.0 International (CC BY 4.0) that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK).
Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK).
License
Articles published in the Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK) are licensed under an Attribution 4.0 International (CC BY 4.0) license. You are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
This license is acceptable for Free Cultural Works. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
