Enhancing Diabetic Foot Ulcer Healing: The Role of Channa striata Extract Nutrition in Accelerating Inflammatory, Proliferative, and Maturation Phases

Authors

DOI:

https://doi.org/10.18196/ijnp.v8i2.20740

Keywords:

Albumin, Channa striata, diabetic foot ulcers, wound healing phases

Abstract

Background: Diabetic foot ulcers pose a severe complication for individuals with diabetes mellitus, necessitating effective therapeutic support such as albumin nutrition throughout the wound healing process. Derived from Channa striata, a commonly consumed source of albumin in Indonesia, this extract can potentially expedite wound healing.

Objective: This study aims to evaluate the efficacy of Channa striata extract nutrition in accelerating the inflammatory, proliferative, and maturation phases of diabetic foot ulcer healing.

Methods: This quantitative study employed a pra-experimental design using a single-group pretest-posttest approach. The study involved 30 diabetic patients who were administered a daily dose of 550 grams of Channa striata extract over four weeks. The Bates Jensen Assessment Tool (BWAT) assessed wound progress.

Results: Results revealed that the average participant age was 60.2 years, with an average diabetic history of seven years. The average wound duration was 8.7 weeks; 66.7% of the participants were female; 70% had Non-Insulin Dependent Diabetes Mellitus (NIDDM); and 56.7% were at stage IV. The study found a significant difference in BWAT scores before and after the administration of Channa striata extract in diabetic foot ulcer patients.

Conclusion: This study supports the effectiveness of Channa striata extract as an adjunct therapy in expediting the wound-healing phases in diabetic foot ulcers.

References

Alejandra Aguayo-Becerra, O., Torres-Garibay, C., Dassaejv Macías-Amezcua, M., Fuentes-Orozco, C., de Guadalupe Chávez-Tostado, M., Andalón-Dueñas, E., Espinosa Partida, A., Álvarez-Villaseñor, A. del S., Cortés-Flores, A. O., & González-Ojeda, A. (2013). Serum albumin level as a risk factor for mortality in burn patients. Clinics, 68(7), 940–945. https://doi.org/10.6061/clinics/2013(07)09

Apriasari, M. L., Puspitasari, D., & Utami, J. P. (2022). Anti-Inflammatory Effect of Channa micropeltes Extract in Angiogenesis of Diabetes Mellitus Wound Healing. Review of Diabetic Studies, 18(4), 166–170. https://doi.org/10.1900/RDS.2022.18.166

Crowley, B., Drovandi, A., Seng, L., Fernando, M. E., Ross, D., & Golledge, J. (2023). Patient Perspectives on the Burden and Prevention of Diabetes-Related Foot Disease. Science of Diabetes Self-Management and Care. https://doi.org/10.1177/26350106231170531

Dewita, D., Sidauruk, S. W., & Desmelati, D. (2022). Amino Acid and Mineral Profiles of Fresh Snakehead ( Channa striata) Meat to Potential as an Immune System. IOP Conference Series: Earth and Environmental Science, 1118(1). https://doi.org/10.1088/1755-1315/1118/1/012034

Everett, E., & Mathioudakis, N. (2018). Update on management of diabetic foot ulcers. Annals of the New York Academy of Sciences, 1411(1), 153–165. https://doi.org/10.1111/nyas.13569

International Diabetes Federation. (2022). IDF Atlas Reports 2022: Diabetes foot-related complications. Idf. www.diabetesatlas.org

Izzaty, A., Dewi, N., & Pratiwi, D. I. N. (2014). Ekstrakharuan(Channa striata)secara efektif menurunkan jumlah limfosit fase inflamasi dalam penyembuhan luka (Extract of haruan (Channa striata) decreases lymphocyte count in inflammatory phase of wound healing process effectively). Journal of Dentomaxillofacial Science, 13(3), 176. https://doi.org/10.15562/jdmfs.v13i3.411

Nurilmala, M., Safithri, M., Pradita, F. T., & Pertiwi, R. M. (2021). Profil Protein Ikan Gabus (Channa striata), Toman (Channa micropeltes), dan Betutu (Oxyeleotris marmorata). Jurnal Pengolahan Hasil Perikanan Indonesia, 23(3), 548–557. https://doi.org/10.17844/jphpi.v23i3.33924

Permana, S. A., Hartono, H., Purwanto, B., & Indarto, D. (2023). Non-inferiority trial of Channa striata extract on endothelial glycocalyx layer protection in septic patients. Anaesthesia, Pain and Intensive Care, 27(4), 523–527. https://doi.org/10.35975/apic.v27i2.2278

Safitri, A. I., Saidah, Q., & Nurhayati, C. (2022). Literatur Review; Pengaruh Pemberian Olahan Ikan Gabus Terhadap Proses Penyembuhan Luka DM. Jurnal Ilmiah Keperawatan Stikes Hang Tuah Surbaya, 17(1), 55–56. https://doi.org/10.30643/jiksht.v17i1.169

Siswanto, A., Dewi, N., & Hayatie, L. (2016). Effect of haruan (channa striata) extract on fibroblast cells count in wound healing. Journal of Dentomaxillofacial Science, 1(2), 89. https://doi.org/10.15562/jdmfs.v1i2.3

Sita Udayanti, & Rini Noviyani. (2023). Pemanfaatan Ekstrak Ikan Gabus (Channa striata) untuk Penyembuh Luka pada Pasien Diabetes Mellitus (Ulkus Diabetikum). Prosiding Workshop Dan Seminar Nasional Farmasi, 1, 50–61. https://doi.org/10.24843/wsnf.2022.v01.i01.p05

Soniya, F., & Fauziah, M. (2020). Efektivitas Ekstrak Ikan Gabus sebagai Antihiperglikemik. Jurnal Penelitian Perawat Profesional, 2(1), 65–70. https://doi.org/10.37287/jppp.v2i1.45

Tai, C.-H., Hsieh, T.-C., Lee, R.-P., & Lo, S.-F. (2021). Prevalence and Medical Resource of Patients with Diabetic Foot Ulcer: A Nationwide Population-Based Retrospective Cohort Study for 2001–2015 in Taiwan. International Journal of Environmental Research and Public Health, 18(4), 1891. https://doi.org/10.3390/ijerph18041891

Tan, S. T., & Dosan, R. (2019). Lessons From Epithelialization: The Reason Behind Moist Wound Environment. The Open Dermatology Journal, 13(1), 34–40. https://doi.org/10.2174/1874372201913010034

Tungadi, R. (2020). Potensi Ikan Gabus (Ophiocephalus Striatus) Dalam Mempercepat Penyembuhan Luka. Jambura Fish Processing Journal, 1(1), 46–55. https://doi.org/10.37905/jfpj.v1i1.4505

Vahwere, B. M., Ssebuufu, R., Namatovu, A., Kyamanywa, P., Ntulume, I., Mugwano, I., Pius, T., Sikakulya, F. K., Xaviour, O. F., Mulumba, Y., Jorge, S., Agaba, G., & Nasinyama, G. W. (2023). Factors associated with severity and anatomical distribution of diabetic foot ulcer in Uganda: a multicenter cross-sectional study. BMC Public Health, 23(1), 1–14. https://doi.org/10.1186/s12889-023-15383-7

Yuliana, B., Sartini, Djide, N., & Djabir, Y. Y. (2022). Wound healing effect of snakehead fish (Channa striata) mucus containing transdermal patch Journal of Applied Pharmaceutical Science. 12(7), 171–183. https://doi.org/10.7324/JAPS.2022.120717

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Published

2024-12-03

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Vol. 8 No. 2 (2024): December

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