Optimization of FDT Turmeric Rhizome Extract (Curcuma domestica Val.) Using a Combination of Crospovidone and Croscarmellose Sodium
DOI:
https://doi.org/10.18196/jfaps.v5i2.24483Keywords:
Optimum Formula, Fast-Disintegrating Tablets, Super Disintegrant, Simplex Lattice DesignAbstract
Turmeric rhizome (Curcuma domestica Val.) is a plant that has anti-diarrheal activity. To get an immediate effect and action in the treatment of diarrhea, turmeric rhizome is formulated into a fast-disintegrating tablet (FDT) dosage form. FDT is strongly influenced by super disintegrant (crushing material). Crospovidone is used as a super disintegrant, as it has a wicking effect (capillary action), while croscarmellose sodium has a swelling effect. The study aims to determine the effect of variations in the concentration of crospovidone and croscarmellose sodium on the physical properties of FDT and determine the optimal concentration of crospovidone and croscarmellose sodium. The sample used was a dry extract of turmeric rhizome. The dried extract of turmeric rhizome was made 5 runs with variations of crospovidone 2–5% and croscarmellose sodium 2–5%. Run 1 (2.75%: 4.25%), run 2 (3.5%: 3.5%), run 3 (5%: 2%), run 4 (2%: 5%), and run 5 (4.25%: 2.75%). The responses used included disintegration time, hardness, and restriction tests. The results utilized to determine the optimum formula were derived from the simplex lattice design (SLD) method. The outcomes of the optimal formula testing experiment were based on the findings from 13.0.5 predictive software experts, employing a one-sample t-test analysis at a 95% confidence level. The results of this study indicate that the combination of crospovidone and croscramellose sodium can reduce the response time of disintegration, hardness, and FDT. The optimum formula was obtained with the variation of crospovidone 3.5% and croscarmellose sodium 3.5%.
References
Kemenkes RI. (2012). Profil Kesehatan Indonesia Tahun 2011. Jakarta: Kementerian Kesehatan Republik Indonesia.
Rachmawati, W. d.Optimasi Formula Tablet Dispersible Ekstrak Daun Jambu Biji Dengan Kombinasi Bahan Penghancur Croscarmellose Sodium dan Sodium Starch Glycolate. Traditional Medicine Journal. 2015
Permata, H. Tanaman Obat Tradisional. Titian Ilmu. 2007
Tjay, T. H. Obat - Obat Penting. Jakarta: PT Gramedia. 2007
Meliala L., Sari W., Tarigan P. Uji Efek Antidiare Ekstrak Rimpang Kunyit (Curcuma domestica val.) Pada Mencit Jantan. Jurnal Penelitian Farmasi Herbal, 2020; Vol.2 No. 2. 15-21. https://doi.org/10.36656/jpfh.v2i2.208
Bhowmik D., C.B., Krishnakanth, Pankaj, Chandira R.M. Fast Disolusing Tablet: An Overview. Journal of Chemical and Pharmaceutical Research. 2009; 1(1): 163-177.
Hidayati, Nurul., Sulaiman T.N.S. & R Nurhaini R. Optimization formula of fast disintegrating tablets Ketoprofen-cyclodextrin inclusion complex with sodium starch glycolate and crospovidone as the superdisintegrants. Journal of Physics: Conference Series; 2020
Putranti, Widyasari., C. A. Formulasi Fast Disintegrating Tablet Ekstrak Etanol Daun Salam dengan Kombinasi Crospovidone dan Croscarmellose Sodium sebagai Superdisintegrants. Jurnal Sains Farmasi & Klinis, 2021; 285–295.
Edityaningrum, T. S. Optimasi Formula Fast Disintegrating Tablet Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) dengan Kombinasi Superdisintegrant Crospovidone dan Croscarmellose Sodium. Traditional Medicine Journal, 2018; 23(I), 62-69.
Rowe, R. C. Handbook of Pharmaceutical Excipients Sixth Edition. Washington DC: Pharmaceutical Press. 2009
Didi, G. Pengaruh Kombinasi Krospovidon, Ac-Di-Sol, dan Primojel Terhadap Waktu Hancur Sediaan Orally Disintegrating Tablet Dimenhidrinat. BIMFI. 2015; 26-31.
Hidayat Rifki, I. A. Z. Design Expert Software Sebagai Alat Optimasi Formulasi Sediaan Farmasi. Majalah Farmasetika, 2021; 99-120.
Fortunata, I. M.R. Pembuatan dan karakterisasi Konjugat Nanopartikel Emas- Kurkumin Termodifikasi Polietilen Glokol = Synthesis and Characterization of Curcumin Conjugated Gold Nanoparticles with Polyethylene Glycol Modification. 2016. https://lib.ui.ac.id/detail?id=20431264&lokasi=lokal
Bintoro, M. d. Analisis dan Identifikasi Senyawa Saponin Dari Daun Bidara (Zhizipus mauritania L.). Jurnal ITEKIMA, 2017; 84-94.
Cobra, H. W. Skirining Fitokimia Ekstrak Sokhletasi Rimpang Kunyit (Curcuma longa) dengan Pelarut Etanol 96%. Jurnal Ilmiah Kesehatan Karya Putra Bangsa, 2019; 12-17.
Rivai, Harrizul., Putri Eka, and Humaira Fadhilah. Pembuatan dan Karakterisasi Ekstrak Kering Daun Sirih Hijau (Pipper betle L.). Jurnal Farmasi Higea, 2014; Vol 6 No 2.
Syukri, Y. Teknologi Sediaan Obat dalam Bentuk Solid. Yogyakarta: Universitas Islam Indonesia; 2018
Kemenkes RI. Farmakope Indonesia Edisi V. Jakarta: Kementerian Kesehatan Republik Indonesia; 2014
Garg A and Gupta MM. Review Article Mouth Dissolving Tablets: a Review. J Drug Deliv Ther. 3 (2), 207-214.
DepKes RI. Farmakope Indonesia Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia; 1995
Jain, C.P and Naruka, P.S. Formulation and evaluation of Fast Dissolving Tablets of Valsartan. International Journal of Pharmacy and Pharmaceutical Science. 2009; 1: 219-221.
DepKes RI. Farmakope Indonesia Edisi III. Jakarta: Departemen Kesehatan Republik Indonesia; 1979
Panigrahi, R. &. A review on Fast Dissolving Tablets; 2010
Sulaiman. (2007). Teknologi & Formulasi Sediaan Tablet. Yogyakarta: Pustaka Laboratorium Teknologi Farmasi Fakultas Farmasi Universitas Gadjah Mada.
Goeswin A. 2007. Pengembangan Sediaan Farmasi. Edisi Revisi dan Perluasan. Bandung. Penerbit ITB.
Syaifullah, M. Y. (2016). Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets. Powder Technology, 396–404.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Nurul Hidayati

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.