Nutritional Status of Hospitalized Tuberculosis Patients in South Kalimantan: A Cross-Sectional Study

Authors

  • Mohamad Isa Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan
  • Ira Nurrasyidah Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan
  • Elok Hikmatun Nikmah Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan
  • Desi Rahmawaty Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan http://orcid.org/0000-0002-0419-9614
  • Ali Assagaf Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan
  • Haryati Haryati Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan
  • Erna Kusumawardhani Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Veteran Sungai Bilu No.128, Melayu, Central Banjarmasin, Banjarmasin, South Kalimantan

DOI:

https://doi.org/10.18196/mmjkk.v22i2.15021

Keywords:

albumin, anemia, Indonesia, tuberculosis, undernutrition

Abstract

The burden of tuberculosis (TB) infection is significant in Indonesia. There is likely a substantial link between TB and malnutrition. Anemia, which is linked to TB patient outcomes and length of hospital stay, is another issue that might aggravate the disease. This study aims to identify how common undernutrition and anemia are among tuberculosis patients at the Ulin Regional Hospital in Banjarmasin. A cross-sectional observational study was conducted using medical record data from 31 hospitalized tuberculosis patients from September to December 2021. Data of weight, height, body mass index (BMI), Hemoglobin (Hb) and blood albumin level at admission were analyzed. The result showed that tuberculosis cases were mostly found in males (61.3%) aged 20-60 years (83.9%). There were 42% of patients with undernutrition (BMI <18.5), 93.5% with anemia, and 71% with hypoalbuminemia. Rifampicin resistance was found in 38.7% of all patients, with 58.3% malnutrition, 100% anemia, and 50% hypoalbuminemia. Thus, there was a possible link between tuberculosis and undernutrition condition. Screening, early diagnosis, and treatment for undernutrition, anemia, and hypoalbuminemia should be encouraged in patients with tuberculosis, whether they are susceptible or resistant to rifampicin, to lower the burden of the disease.

References

World Health Organization. Global tuberculosis report [Internet]. 2021 [cited 2022 Jun 4]. https://www.who.int/publications/i/item/9789240037021

Kementrian Kesehatan Republik Indonesia. Dashboard Tuberculosis Indonesia [Internet]. 2021 [cited 2022 Jun 4]. https://tbindonesia.or.id/pustaka-tbc/dashboard-tb/

Kemenkes RI. Strategi Nasional Penanggulangan Tuberkulosis di Indonesia 2020-2024 [Internet]. Pertemuan Konsolidasi Nasional Penyusunan STRANAS TB. 2020 [cited 2022 Jun 1]. p. 135. https://tbindonesia.or.id/wp-content/uploads/2021/06/NSP-TB-2020-2024-Ind_Final_-BAHASA.pdf

Kemenkes RI. Profil Kesehatan Indonesia Tahun 2020 [Internet]. 2021 [cited 2022 Jun 1]. https://www.kemkes.go.id/downloads/resources/download/pusdatin/profil-kesehatan-indonesia/Profil-Kesehatan-Indonesia-Tahun-2020.pdf

TB deaths and incidence. In: Global tuberculosis report. Geneva: World Health Organization; 2021. p. 13–4.

Kurnia AD, Masruroh N, Melizza N. Factors Related to the Low Nutritional Status among Tuberculosis Patients. J Keperawatan Padjadjaran. 2020;8(1):42–8. https://doi.org/10.24198/jkp.v8i1.1294

Wondmieneh A, Gedefaw G, Getie A, Demis A. Prevalence of undernutrition among adult tuberculosis patients in Ethiopia: A systematic review and meta-analysis. J Clin Tuberc Other Mycobact Dis. 2021;22:100211. https://doi.org/10.1016/j.jctube.2020.100211

Lai HH, Lai YJ, Yen YF. Association of body mass index with timing of death during tuberculosis treatment. PLoS One. 2017;12(1):1–12. https://doi.org/10.1371/journal.pone.0170104

Appiah PK, Osei B, Amu H. Factors associated with nutritional status, knowledge and attitudes among tuberculosis patients receiving treatment in Ghana: A cross-sectional study in the Tema Metropolis. PLoS One. 2021;16(10 October):1–12. https://doi.org/10.1371/journal.pone.0258033

World Health Organization. Haemoglobin concentrations for the diagnosis of anemia and assessment of severity [Internet]. Geneva, Switzerland: World Health Organization. 2011 [cited 2022 Jun 2]. p. 1–6. https://apps.who.int/iris/bitstream/handle/10665/85839/WHO_NMH_NHD_MNM_11.1_eng.pdf

World Health Organization. Body mass index [Internet]. Geneva, Switzerland: World Health Organization. 2020 [cited 2022 Jun 1]. https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi

Aljohaney AA. Mortality of patients hospitalized for active tuberculosis in King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Saudi Med J. 2018;39(3):267–72. https://doi.org/10.15537/smj.2018.3.22280

Shrivastava P, Bagchi T. Testosterone in the pathogenesis of tuberculosis. Chem Biol Lett. 2021;8(4):238–47.

Kubiak RW, Sarkar S, Horsburgh CR, Roy G, Kratz M, Reshma A, et al. Interaction of nutritional status and diabetes on active and latent tuberculosis: A cross-sectional analysis. BMC Infect Dis. 2019;19(1):1–9. https://doi.org/10.1186/s12879-019-4244-4

Amere GA, Nayak P, Salindri AD, Narayan KMV, Magee MJ. Contribution of smoking to tuberculosis incidence and mortality in high-tuberculosis-burden countries. Am J Epidemiol. 2018;187(9):1846–55. https://doi.org/10.1093/aje/kwy081

Hertz D, Schneider B. Sex differences in tuberculosis. Semin Immunopathol. 2019;41(2):225–37. https://doi.org/10.1007/s00281-018-0725-6

Perumal R, Naidoo K, Padayatchi N. TB epidemiology: Where are the young women? Know your tuberculosis epidemic, know your response. BMC Public Health. 2018;18(1):1–6. https://doi.org/10.1186/s12889-018-5362-4

Medyantari NPA, Soedarsono S, Wahyunitisari MR. the Correlation Between Sex, Age, Nutritional Status and Diabetes Mellitus With Clinical Symptoms Mdr Pulmonary Tb At Rsud Dr Soetomo. J Kedokt Syiah Kuala. 2019;19(2). https://doi.org/10.24815/jks.v19i2.18063

Gurung LM, Bhatt LD, Karmacharya I, Yadav DK. Dietary Practice and Nutritional Status of Tuberculosis Patients in Pokhara: A Cross-Sectional Study. Front Nutr. 2018;5(August):3–8. https://doi.org/10.3389/fnut.2018.00063

Chandrasekaran P, Saravanan N, Bethunaickan R, Tripathy S. Malnutrition: Modulator of immune responses in tuberculosis. Front Immunol. 2017;8(OCT):1–8. https://doi.org/10.3389/fimmu.2017.01316

Ganesan H, Gopinath P. Prevalence of hypoalbuminemia among tuberculosis patients receiving anti-tuberculosis therapy: A cross-sectional study. Int J Adv Biochem Res. 2019;3(2):09–13. https://doi.org/10.33545/26174693.2019.v3.i2a.34

Gelaw Y, Getaneh Z, Melku M. Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis. Environ Health Prev Med. 2021;26(1):1–15. https://doi.org/10.1186/s12199-020-00931-z

Dignass A, Farrag K, Stein J. Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions. Int J Chronic Dis. 2018;2018(Table 1):1–11. https://doi.org/10.1155/2018/9394060

Feleke BE, Feleke TE, Mekonnen D, Beyene MB. Micronutrient levels of tuberculosis patients during the intensive phase, a prospective cohort study. Clin Nutr ESPEN. 2019;31:56–60. https://doi.org/10.1016/j.clnesp.2019.03.001

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Published

2022-07-31

Issue

Vol. 22 No. 2 (2022): July

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Research

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