Peran Imunisasi dalam Pencegahan Hepatitis B pada Pegawai Universitas Muhammadiyah Yogyakarta
DOI:
https://doi.org/10.18196/mmjkk.v9i2%20(s).1608Keywords:
Anti-HBs, Anti-HBc, HBs Ag, imunisasi, Hepatitis B, immunizationAbstract
The purpose this research is to know endemicity level and prevention hepatitis B. This is a descriptif observational research. Subjects are 87 Medical Faculty of UMY employee. Screening to HBsAg, anti-HBs and anti-HBc are performed by enzyme-linked immunosorbent assay (ELISA) method and investigating about history of ilness and imunisation of hepatitis B by questionnaire. The result showed that one case positive HBsAg (1,1%) included as low endemicity and not found clinical manifestasion. The history showed that 14 person (16 %) have performed hepatitis B immunization, and 73 person (74 %) have never done. Six subject (43%) immunizationed showed positive anti-HBs with low titer. Hepatitis B history are experienced by two person (2,3%), and they have been health based on clinic and laboratory. One of them has anti-HBc negative. Anti-HBs examination showed 18 (21%) positively, 6 person (33%) have immunization history and 12person (67%) are never. There are 8person who have immunization history are negative anti-HBs. Anti-HBc examination showed that 25person (29%) positively, only one person (4%) has hepatitis B illness history and 24person (96%) have no illness history. Concluded that hepatitis endemicity in Medical Faculty UMY is low.
Tujuan penelitian ini untuk mengetahui tingkat endemisitas dan upaya pencegahan Hepatitis B di FK UMY. Jenis penelitian adalah observasional deskriftif. Sampel penelitian adalah 87 pegawai Fakultas Kedokteran UMY. Skrining HBsAg, Anti HBs dan Anti HBc dilakukan dengan metode enzyme- linked immunosorbent assay {ELISA), riwayat sakit dan imunisasi hepatitis B dilacak dengan kuesioner. Hasil penelitian menunjukkan terdapat satu kasus HBsAg positip (1,1%) sehingga termasuk endemis rendah dan anamnesanya menunjukkan tidak ada gejala klinis. Riwayat menunjukkan 14 orang (16%) pernah melakukan imunisasi hepatitis B lengkap dan 73 orang (74%) tidak pernah divaksin. Enam orang (43%) dari yang melakukan imunisasi, memiliki anti-HBs positip dengan titer rendah. Riwayat pernah mengalami sakit hepatitis B terjadi pada 2 orang (2,3%) dan telah sembuh secara klinis dan laboratorik. Salah satu subyek dengan riwayat sakit hepatitis B memiliki hasil anti- HBc negatif. Pemeriksaan anti-HBs menunjukkan 18 orang (21%) positip, 6 orang (33%) diantaranya memiliki riwayat imunisasi dan 12 orang (67%) tidak pernah imunisasi. Delapan orang dengan riwayat imunisasi memiliki anti-HBs negatif. Pemeriksaan anti-HBc menunjukkan 25 orang (29%) positip, 1 orang (4%) diantaranya memiliki riwayat sakit hepatitis B, dan 24 orang (96%) tidak memiliki riwayat sakit hepatitis B. Disimpulkan bahwa endemisitas Hepatitis B di Fakultas Kedokteran Universitas Muhammadiyah Yogyakarta rendah.
References
Lee, W.M., 1997. Hepatitis B Infection. N Engl J Med. 337 :1733-1745.
Mahoney, F.J., 1999. Update on Diagnosis, Management, and Prevention of Hepatitis B Virus Infection. Clin Microbiol Rev. 12 :351-366
Chin, J., 2000. Control of Communicable Disease Manual. 17th Edition. Washington DC, American Public Health Association,
Hernomo, K. 1999. Perkembangan Baru Pengobatan Hepatitis Virus B. Simposium Perkembangan Mutakhir di Bidang Gastro-hepatologi. Surabaya.23 Oktober.
Sulaiman, A., 1995. Virus Hepatitis A-E di Indonesia, Ikatan Dokter Indonesia Jakarta, 16-37
CDC. 1997. Immunization of health¬Care Workers: Recommendation of the advisory Committee on Immunization Practise (ACIP) and the Hospital Infection Control Practise Advisory Committee (HICPAC). MMWR.;46:RR- 18
Jagger, J., Bentley, M., Juillet, E., 1998. Direct Cost of Follow-up for Percutaneous and Mucocutaneous Exposures to At-risk Body Fluids: Data from Two Hospitals. Adv Exposure Prev;3:25, 34-5.
Husa, P, Husova, L., 2004. What Risk is a Health Care Worker Infected with Hepatitis B or C Virus for His Patients? Vnitr Lek. Oct;50(10):771-6.
Azap, A., Ergonul, O., Memikoglu, K.O., Yesilkaya, A., Altunsoy, A., Bozkurt, G.Y., Tekeli, E., 2005.Occupational Exposure to Blood and Body Fluids among Health Care Workers in Ankara. Turkey.American Journal Infection Control Feb;33(1):48-52.
CDC, 1988. Update: Universal Precautions for Prevention of Transmission of Human Immunodeficiency Virus, Hepatitis B Virus, and Other Bloodborne Pathogens in Health-Care Settings. MMWR;37:377—82,387—8.
Shapiro, C.N., Tokars, J.I., Chamberland, M.E., et al, 1996. Use of The Hepatitis B Vaccine and Infection with Hepatitis B and C among Orthopaedic Surgeons. J Bone Joint Surg;78-A:1791-1800.
Suwignyo, Nurul, A., 1987. Hepatitis Virus B dalam Ilmu Penyakit Dalam. Edisi kedua, Suparman editor. 593-601
Kaniawati, 1997. Gambaran Serologis dan Biokimia pada Infeksi Virus Hepatitis B. Forum Diagnosticum Laboratorium Klinik Prodia Yogyakarta. Seri ISSN 0854-7516, no 4
Don Ganem & Alfred M., 2004. Hepatitis B Virus Infection — Natural History and Clinical Consequences. NEJM 350(12) :1119-29).
Diel, R., Helle, J., Gottschalk, R., 2005. Transmission of Hepatitis B in Hamburg, Germany, 1998-2002: a prospective, population-based study. Med Microbiol Immunol (Berl). Mar 15;
Sagliocca, L.T., Stroffolini, P, Amoroso, et al, 1997. Risk Factors for Acute Hepatitis B: A Case-control Ctudy . Viral Hepat, January 1,; 4(1): 63-6.
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