Pengaruh Virgin Coconut Oil terhadap Kadar Kolesterol, HDL dan LDL Tikus Putih (Rattus norvegicus)
DOI:
https://doi.org/10.18196/mmjkk.v8i1%20(s).1641Keywords:
kolesterol, LDL, HDL, cholesterol, Virgin Coconut OilAbstract
Recently, cardiovascular disease becomes an obstacle to do a daily activities. VCO is one of the solutions to decrease cholesterol blood score.The aim of this research is to know the influence of VCO (Virgin Coconut Oil) toward cholesterol, LDL and HDL score on Rattus norvegicus. The research design used an experimental laboratory in vivo on animah test which used Rattus norvegicus, Spraque Dawley strain, 2 months age, 130-215g body weight as subject. Twenty rats were divided into 4 groups. Three groups were VCO ’s treatment and 1 group was a control group. Those 3 groups were given three different VCO ’s brand each others orally everyday during 30 days and the formula doses were converted with human dose standard. Then on 31st day, all rats are killed to check the blood score with micro capillary pipe. The blood score were measured by Spectrophotometer and analyzed by ANOVA one way, continued with Tukey Test. Cholesterol and LDL score which given VCO treatment, its score higher than control group. HDL score on the group which given VCO lower than control group. There is not any significant (P > 0.05)between the influence of VCO toward Rattus norvegicus’ cholesterol, LDL and HDL score.
Akhir-akhir ini penyakit kardiovaskuler dapat mengganggu aktifitas kerja, sehingga manusia mencari jalan keluar untuk mengatasinya. Salah satunya dengan cara menggunakan VCO yang dapat menurunkan kadar kolesterol darah. Tujuan penelitian ini adalah untuk mengetahui pengaruh VCO (Virgin Coconut Oil) yang berada di pasaran terhadap kadar kolesterol, LDL, dan HDL tikus putih (Rattus norvegicus). Desain penelitian ini adalah penelitian eksperimental in vivo pada hewan uji dengan tikus putih (Rattusnorvegicus) galur SD jantan umur 2 bulan, berat badan 130-215g. Duapuluh ekor tikus putih dibagi menjadi 4 kelompok yaitu: 3 kelompok perlakuan dan 1 kelompok kontrol. Kelompok perlakuan diberi VCO dengan 3 merek berbeda per oral setiap hari selama 30 hari dengan dosis yang dikonversikan dari dosis pada manusia. Pada hari ke 31 tikus dikorbankan, diperiksa darah menggunakan pipa kapiler. Hasil kadar kolesterol diukur menggunakan Spektrofotometri, dan dianalisis menggunakan uji Anova satu jalan dilanjutkan uji Tukey. Hasil penelitian menunjukkan bahwa kadar kolesterol dan LDL kelompok perlakuan yang diberi VCO lebih tinggi daripada kelompok kontrol dan secara statistik tidak berbeda secara bermakna (p>0,05). KadarHDL kelompok yang diberi VCO lebih rendah daripada kelompok kontrol dan secara statistik juga tidak signifikan (p>0,05).
References
Weil. (2000). What Difference Between MCT and LCT. Diakses 8 Oktober 2006, dari http://www.cdc.gov/labstandards/ crmln.htm
Syah, A.N.A. (2005). Kelapa: Masihkah Memberi Harapan?, Virgin Cocout Oil Minyak Penakluk Aneka Penyakit. 1-9. AgroMedia Pustaka. Jakarta
Anonim, (2007). Americanheart. Cholesterol. Diakses 4 Januari 2007, dari http://www.americanheart.org// presenter.ihtml?identitier=18QAboutCholesterol
Anonim, (2007). American Heart Association : What Is Cholesterol? Diakses 4 Januari 2007, dari http:// presenter.ihtml.htmcholesterol.htm
Syah, A.N.A.(2005). Karakteristik Fisiko- kimia Minyak Kelapa, Virgin Coconut Oil Minyak penakluk Aneka Penyakit. 10¬27. AgroMedia Pustaka. Jakarta.
Ngatijan. (1991). Petunjuk Laboratorium
: Metode Laboratorium dalam
Toksikologi. Yogyakarta: Pusat Analisa Bioteknologi Universitas Gadjah Mada.
Lam, L. (2007).Services Heart Attack. Diakses 22 Maret 2007, dari http:// www.cardiaccenter.org//article
Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W. (2003). Pengangkutan dan Penyimpanan Lipid, dalam Buku Kedokteran Biokimia Harper. 254-269. EGC. Jakarta.
Guyton, A.C., Hall, J.E. (1997). Metabolisme Lemak, dalam Buku Ajar Fisiologi Kedokteran. 1077-1088. EGC. Jakarta.
Dayrit, C.S. (2003). COCONUT OIL: Atherogenic or Not. Philippine Journal of Cardiology, Volume 31. Diakses 8 Januari 2007, dari http:// www.coconutresearchcenter.org// article/pdf
Downloads
Published
Issue
Section
License
Copyright
Authors retain copyright and grant Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK) the right of first publication with the work simultaneously licensed under an Attribution 4.0 International (CC BY 4.0) that allows others to remix, adapt and build upon the work with an acknowledgment of the work's authorship and of the initial publication in Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK).
Authors are permitted to copy and redistribute the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK).
License
Articles published in the Mutiara Medika: Jurnal Kedokteran dan Kesehatan (MMJKK) are licensed under an Attribution 4.0 International (CC BY 4.0) license. You are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
This license is acceptable for Free Cultural Works. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
