Pemilihan Terapi pada Kutil Genital
Abstract
Genital warts (GC) is one of the most common STDs and associated with cervical cancer or genital cancer. This paper will explain the various treatment modalities and how to vote on the GC. GC could be spontaneous resolution, making it one of the treatment options and treatment will be given if clinically visible or enlarged lesions. Treatment modality of GC are grouped into 3, antitumor (cytotoxic andphysical ablative), immunomodulatory and antiviral. Election of treatment modalities is influenced by various factors, like the number, size and place of the lesion, the shape of the lesion, patient preference, cost, side effects, physician experience and specific conditions of patient such as pregnancy, children and immunocompromised patients.
Kutil genital (KG) merupakan salah satu PMS yang paling sering terj adi dan berhubungan dengan kanker servik atau kanker genital. Tulisan ini akan menj elaskan berbagai modalitas dan cara pemilihan terapi pada kutil genital. KG dapat mengalami resolusi spontan, sehingga salah satu pilihan terapi dengan membiarkan dan terapi hanya diberikan jika secara klinis tampak atau lesi membesar. Modalitas terapi KG dikelompokkan menjadi 3, yaitu preparat antitumor (sitotoksik dan ablatif fisik), dan imunomodulator dan antivirus. Pemilihan terapi KG dipengaruhi oleh berbagai faktor, antara lain: jumlah, ukuran dan tempat lesi, bentuk lesi, kesukaan pasien, biaya, efek samping dan pengalaman dokter serta kondisi khusus pasien seperti kehamilan, anak-anak dan penderita imunokompromais.
Keywords
Full Text:
PDFReferences
Koutsky LA, Kiviat NB,. Genital human papilloma virus, Holmes KK, Mardh PA, Sparling PF, dkk., Sexually Transmitted Diseases, 3rd Ed, 1999, McGraw-Hill, Singapore: 347-360.
Ting PT, Dytoc MT,. Therapy of external anogenital warts and moluscum contagiosum: a literature review, Dermatol Therapy, 2004; 17: 68-101.
Wiley DJ, Douglas J, Beutner K, dkk,. External genital warts: diagnosis, treatment, and prevention, CID, 2002; 35: s210-s224.
Lacey CJN, Goodall RL, Tennvall GR, dkk., randomized controlled trial and economic evaluation of podophilloxin solution, podophyllotoxin cream and podophyllin in the treatment of genital warts, Sex Transm Infect, 2003; 79:270-275.
Persson G, Andersson K, Krantz I. Symptomatic genital papillomavirus infection in a community - incidence and clinical picture. Acta Obstet Gynecol Scand 1996; 75: 287-290. (abstrak).
Severson J, Evans TY, Lee P, dkk,. Human papilloma virus infections: epidemiology, pathogenesis and therapy, J Cutan Med Surg, 2001; 5:43-60.
Lowy DR, Androphy EJ,. Warts, dalam Freedberg I.M., Eisen A.Z., Wolff K., Austen K.F.. Dermatology in General Medicine, 5th ed.. New York, Mc Graw- Hill Inc.: 2484-2495.
Sanclamente G, Gill DK, Human papilloma virus, molecular biology and pathogenesis, J Eur Acad Dermatol Venereol, 2002: 16: 231-240.
Kodner CM, Nasraty S,. Management of genital warts, Am Fam Physicians, 2004; 70: 2335-2342.
Tuncel A, Gorgu M, Ayhan M, dkk. Treatment of anogenital warts by pulsed dye laser, Dermatol Surg, 2002; 28: 350-352.
Fife KH, Ferenzy A, Douglas JM, dkk,. Treatment of external genital warts in men using imiquimod 5% cream applied three times a week, once daily, twice daily or three times a day, Sex Transm Dis, 2001; 28: 226-231.
Syed TA, Hadi SM, Qureshi ZA, dkk,. Treatment of external genital warts in men with imiquimod 2% in cream: a placebo-controlled , double blind study, J Infect Dis, 2000; 41: 148-151.
Stanley M, Chapter 17: Genital HPV infections- current and prospective therapies, J Natl Cancer Inst Monograf, 2003; 31: 117-124.
Wang XL, Wang HW, Xu SZ dkk,. Topical ALA-PDT therapy for the treatment of urethral condyloma accuminata, Br J Dermatol, 2004; 151: 880-885.
Herzinger T, Wienecke R, Weisenseel P, dkk,. PDT of genital condyloma in men, Clin ExprDermatol, 2005; 31: 51¬53.
Keay S, Teng N, Eisenberg, dkk,. Topical interferon for treating condyloma accuminata in women, J Infect Dis, 1988: 158: 9340939. (abstrak)
Olsen EA, Kelly FF, Volmer RT, dkk,. Comparative study of systemic interferon alfa and isotretinoin in the treatment of resistant condyloma accuminata, J Am Acad Dermatol, 1989; 20: 1023-1030.
Gelmetti C, Cerri D Schiuma AA, Menni S, Treatment of extensive warts with etritinate: a clinical trial in 20 children, Pedriatr Dermatol, 1987: 4: 254-258 (abstrak).
Gibbs S, Harvey I, Sterling J, dkk,. Local treatments for cutaneous warts: systemic review, British Medical Journal, 2002; 325: 461.
Koutsky LA, Ault KA, Wheeler CM, dkk,. A controlled trial of HPV type 16 vaccine, N Engl J Med, 2002; 347: 1645-1651.
Anonim, Genital human papilloma virus infection, National terwork of STD/HIV Prevention Training Centers, Genital HPV Infections, 2003, 1-20.
Alam M, Stiller M,. Direct medical costs for surgical and medical treatment of condyloma accuminata, Arch Dermatol, 2001; 137: 337-341 (abstrak).
Robinson AJ, Watkeys JEM,. Genital warts in children: problems of management, J of Clin Forensic Med, 1999; 6: 151-155.
Johnson PJ, Mirzai TH, Bentz ML,. Carbon dioxide laser ablation of anogenital condyloma acuminata in pediatric patients, Ann Plast Surg. 1997 Dec;39(6):578-82 (abstrak)
Franco I,. Oral cimetidine for the management of genital and perigenital warts in children, J Urol. 2000 Sep; 164(3 Pt 2):1074-5 (abstrak).
Kilewo CD, Urassa WK, Pallangyo K, dkk,. Response to podophillotoxin treatment of genital warts in relation to HIV-1 infection among patients in Dar Es Salaam, Tanzania, Int J STD AIDS, 1995; 6: 114-116 (abstrak).
Snoeck R, Bossens M, Paarent D, dkk,. Phase II double-blind, placebo- controlled study of the safety and efficacy of cidofovir topical gel for the treatment HPV infection, CID, 2001; 33: 597-602.
Calista D,. Topical cidofovir for severe cutaneous HPV and moluscum contagiosum infection in patients with HIV/AIDS. A pilot study. J Eur Acad Dermato Venereol, 2000; 14: 484-488.
DOI: https://doi.org/10.18196/mmjkk.v7i2%20(s).1667
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Editorial Office:
Journal Room, G1 (Biomedic) Building, Ground Floor, Faculty of Medicine and Health Science Universitas Muhammadiyah Yogyakarta,
Jalan Lingkar Selatan (Brawijaya), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta, Indonesia
Phone: +62 274 387 656 (ext: 231)
WA : +62 811-2650-303
Website: http://journal.umy.ac.id/index.php/mm
E-mail: mmjkk@umy.university
Mutiara Medika: Jurnal Kedokteran dan Kesehatan is licensed under a Creative Commons Attribution 4.0 International License. View My Stats