Poliunsaturated Fatty Acid (Pufa) Dapat Memodulasi Efek Polimorfisme Apoal G-a terhadap Kadar Hdl-kolesterol pada Sifat Jenis Kelamin Tertentu: Penelitian di Framingham
DOI:
https://doi.org/10.18196/mmjkk.v4i1.1712Abstract
Latar belakang : Substitusi G menjadi A di daerah promoter (pasangan basa 75) pada gen Apolipoprotein Al (APOA1) secara umum sudah dijelaskan. Di beberapa penelitian, allel A tampak berhubungan dengan peninggian kadar HDL-kolesterol tetapi tidak pada penelitian lain.
Tujuan : Menilai bagaimana diet lemak dapat memodulasi huubngan antara polimorfisme dengan kadar HDL-kolesterol.
Design : Populasi yang digunakan sebanyak 755 pria dan 822 wanita di Framingham Offspring Studi.
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