Changes in Women’s Menstruation Cycle After COVID-19 Vaccination and Infection

Maria Ulfa, Seshy Tinartayu, Dwi Kartika Nur Fitriani, Sweetina Merkusi, Varianidia Veterini

Abstract


Since the COVID-19 case was discovered, Indonesia has been one of the affected nations and found various COVID-19 infection and immunization risks. Most females are in the menstrual cycle following COVID-19 infection, regardless of the number of days between cycles, blood quantity, or menses duration. This study examines the changes in menstruation post-COVID-19 infection and vaccination. This study used a cross-sectional observational study with an online questionnaire. The 758 female respondents in Yogyakarta were divided into two groups: 532 females who received vaccination and never have been infected with COVID-19 (Group A) and 226 females with a history of being infected with COVID-19 and vaccination (Group B). The data was analyzed using SPSS 26. The results found that most respondents aged 17-25 (90.24%) were students (80.87%). Both two groups had acne on Pre-menstrual syndrome (28.16%), 5-8 days of menstrual duration (73.75%), <30 days of menstruation duration length (57%), and the regular menstruation volume (63.19%) after COVID-19 vaccination. The comparative analysis of menstruation changes in two groups (p>0.05), including menstrual duration (0.771), menstrual duration length (0.609), and menstrual volume (0.476) after COVID-19 vaccination. In conclusion, there was no significant difference in menstrual change between Group A and Group B. After vaccination, healthcare professionals can promote post-COVID-19 immunization counseling and services to women who experience an abnormal menstrual cycle.

Keywords


COVID-19; COVID-19 vaccination; menstrual change

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References


Chairani I. Dampak Pandemi Covid-19 Dalam Perspektif Gender Di Indonesia. J Kependud Indones. 2020;39. http://dx.doi.org/10.14203/jki.v0i0.571

Fakhriani R, Ulfa M, Maryani N, Sutantri S, Permana I, Setyonugroho W. Investigating knowledge toward COVID-19 vaccination: A cross-sectional survey in Yogyakarta, Indonesia. Open Access Maced J Med Sci. 2022;10(E):865–74. http://dx.doi.org/10.3889/oamjms.2022.9104

Merchant H. COVID-19 post-vaccine menorrhagia, metrorrhagia or postmenopausal bleeding and potential risk of vaccine-induced thrombocytopenia in women. The BMJ (2021).

Abdollahi A, Naseh I, Kalroozi F, Kazemi-Galougahi MH, Nezamzadeh M, Sabeti Billandi S, et al. Comparison of Side Effects of COVID-19 Vaccines: Sinopharm, AstraZeneca, Sputnik V, and Covaxin in Women in Terms of Menstruation Disturbances, Hirsutism, and Metrorrhagia: A Descriptive-Analytical Cross-Sectional Study. International Journal of Fertility and Sterility 16, 237–243 (2022). http://dx.doi.org/10.22074/ijfs.2022.544706.1236

Kadali RAK, Janagama R, Peruru S, Malayala SV. Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers. Int J Infect Dis. 2021;106:376–81. http://dx.doi.org/10.1016/j.ijid.2021.04.047

Edelman A, Boniface ER, Male V, Cameron ST, Benhar E, Han L, et al. Association between menstrual cycle length and covid-19 vaccination: global, retrospective cohort study of prospectively collected data. BMJ Med. 2022;1(1):e000297 http://dx.doi.org/10.1136/bmjmed-2022-000297

Alghamdi AN, Alotaibi MI, Alqahtani AS, Al Aboud D, Abdel-Moneim AS. BNT162b2 and ChAdOx1 SARS-CoV-2 post-vaccination side-effects among Saudi vaccinees. Front Med (Lausanne). 2021;8. http://dx.doi.org/10.3389/fmed.2021.760047

Alvergne A, Kountourides G, Argentieri MA, Agyen L, Rogers N, Knight D, et al. COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study. bioRxiv. 2021. http://dx.doi.org/10.1101/2021.11.23.21266709

Lee KMN, Junkins EJ, Luo C, Fatima UA, Cox ML, Clancy KBH. Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination. bioRxiv. 2021. http://dx.doi.org/10.1101/2021.10.11.21264863

Laganà AS, Veronesi G, Ghezzi F, Ferrario MM, Cromi A, Bizzarri M, et al. Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey. Open Med (Warsz). 2022;17(1):475–84. http://dx.doi.org/10.1515/med-2022-0452

Suzuki S, Hosono A. No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study. Papillomavirus Res. 2018;5:96–103. http://dx.doi.org/10.1016/j.pvr.2018.02.002

Dabbousi AA, El Masri J, El Ayoubi LM, Ismail O, Zreika B, Salameh P. Menstrual abnormalities post-COVID vaccination: a cross-sectional study on adult Lebanese women. Ir J Med Sci. 2023;192(3):1163–70. http://dx.doi.org/10.1007/s11845-022-03089-5

Taşkaldıran I, Vuraloğlu E, Bozkuş Y, Turhan İyidir Ö, Nar A, Başçıl Tütüncü N. Menstrual changes after COVID-19 infection and COVID-19 vaccination. Int J Clin Pract. 2022;2022:1–5. http://dx.doi.org/10.1155/2022/3199758

Al-Najjar MAA, Al-alwany RR, Al-Rshoud FM, Abu-Farha RK, Zawiah M. Menstrual changes following COVID-19 infection: A cross-sectional study from Jordan and Iraq. PLoS One. 2022;17(6):e0270537. http://dx.doi.org/10.1371/journal.pone.0270537

Amer AA, Amer SA, Alrufaidi KM, Abd-Elatif EE, Alafandi BZ, Yousif DA, et al. Menstrual changes after COVID-19 vaccination and/or SARS-CoV-2 infection and their demographic, mood, and lifestyle determinants in Arab women of childbearing age, 2021. Front Reprod Health. 2022;4. http://dx.doi.org/10.3389/frph.2022.927211

Edelman A, Boniface ER, Benhar E, Han L, Matteson KA, Favaro C, et al. Association between menstrual cycle length and Coronavirus disease 2019 (COVID-19) vaccination: A U.s. cohort. Obstet Gynecol. 2022;139(4):481–9. http://dx.doi.org/10.1097/aog.0000000000004695

Alvergne A, Woon EV, Male V. Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts. Front Reprod Health. 2022;4. http://dx.doi.org/10.3389/frph.2022.952976

Wang S, Mortazavi J, Hart JE, Hankins JA, Katuska LM, Farland LV, et al. A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics. Am J Obstet Gynecol. 2022;227(5):739.e1-739.e11. http://dx.doi.org/10.1016/j.ajog.2022.07.003

Lee KMN, Junkins EJ, Luo C, Fatima UA, Cox ML, Clancy KBH. Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination. Sci Adv. 2022;8(28). http://dx.doi.org/10.1126/sciadv.abm7201

Male V. Menstrual changes after covid-19 vaccination. BMJ. 2021;n2211. http://dx.doi.org/10.1136/bmj.n2211

Najib N, Triwijayanti U, Utomo W. Demographic characteristics related to first married age in Indonesia. J Kesehat Masy. 2021;17(1):94–101. http://dx.doi.org/10.15294/kemas.v17i1.26144

Rosner J, Samardzic T, Sarao MS. Physiology, Female Reproduction. [Updated 2022 Jul 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537132/

Rimon-Dahari N, Yerushalmi-Heinemann L, Alyagor L, Dekel N. Ovarian Folliculogenesis. Molecular Mechanisms of Cell Differentiation in Gonad Development. 2016;167–90. http://dx.doi.org/10.1007/978-3-319-31973-5_7

Coast E, Lattof SR, Strong J. Puberty and menstruation knowledge among young adolescents in low- and middle-income countries: a scoping review. Int J Public Health. 2019;64(2):293–304. http://dx.doi.org/10.1007/s00038-019-01209-0

Pan B, Li J. The art of oocyte meiotic arrest regulation. Reprod Biol Endocrinol. 2019;17(1). http://dx.doi.org/10.1186/s12958-018-0445-8

Ahmed M, Bondje S, Jiwan R, Rawther F, Duku A, Husain N, et al. Early menopause in acquired immunodeficiency syndrome. J Res Med Sci. 2021;26(1):122. http://dx.doi.org/10.4103/jrms.jrms_691_19

Kojic EM, Wang CC, Cu-Uvin S. HIV and menopause: A review. J Womens Health (Larchmt). 2007;16(10):1402–11. http://dx.doi.org/10.1089/jwh.2007.0345

El Khoudary SR. Age at menopause onset and risk of cardiovascular disease around the world. Maturitas. 2020;141:33–8. http://dx.doi.org/10.1016/j.maturitas.2020.06.007

Thiyagarajan DK, Basit H, Jeanmonod R. Physiology, Menstrual Cycle. [Updated 2022 Oct 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK500020/

Moy G, Gupta V. Menstrual-Related Headache. [Updated 2022 Oct 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557451/

Ding T, Wang T, Zhang J, Cui P, Chen Z, Zhou S, et al. Analysis of ovarian injury associated with COVID-19 disease in reproductive-aged women in Wuhan, China: An observational study. Front Med (Lausanne). 2021;8. http://dx.doi.org/10.3389/fmed.2021.635255

Lebar V, Laganà AS, Chiantera V, Kunič T, Lukanović D. The effect of COVID-19 on the menstrual cycle: A systematic review. J Clin Med. 2022;11(13):3800. http://dx.doi.org/10.3390/jcm11133800

Warner P, Whitaker LHR, Parker RA, Weir CJ, Douglas A, Hansen CH, et al. Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM). EBioMedicine. 2021;69(103434):103434. http://dx.doi.org/10.1016/j.ebiom.2021.103434

Wang YX, Arvizu M, Rich-Edwards JW, Stuart JJ, Manson JE, Missmer SA, et al. Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ. 2020;m3464 http://dx.doi.org/10.1136/bmj.m3464

Mihm M, Gangooly S, Muttukrishna S. The normal menstrual cycle in women. Anim Reprod Sci. 2011;124(3–4):229–36. http://dx.doi.org/10.1016/j.anireprosci.2010.08.030

Nagma S. To Evaluate the Effect of Perceived Stress on Menstrual Function. J Clin Diagn Res. 2015. http://dx.doi.org/10.7860/jcdr/2015/6906.5611

Campbell LR, Scalise AL, DiBenedictis BT, Mahalingaiah S. Menstrual cycle length and modern living: a review. Curr Opin Endocrinol Diabetes Obes. 2021;28(6):566–73. http://dx.doi.org/10.1097/med.0000000000000681

Minakshi R, Rahman S, Ayaggari A, Dutta D, Shankar A. Understanding the trauma of menstrual irregularity after COVID vaccination: A bird’s-eye view of female immunology. Front Immunol. 2022;13. http://dx.doi.org/10.3389/fimmu.2022.906091

Filfilan NN, Bukhari S, Rizwan M, Bukhari NM, Aref NK, Arain FR, et al. Effects of different types of COVID-19 vaccines on menstrual cycles of females of reproductive age group (15-49): A multinational cross-sectional study. Cureus. 2023 http://dx.doi.org/10.7759/cureus.39640

Foster C, Al-Zubeidi H. Menstrual irregularities. Pediatr Ann. 2018;47(1). http://dx.doi.org/10.3928/19382359-20171219-01

Munro MG, Critchley HOD, Fraser IS, the FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143(3):393–408. http://dx.doi.org/10.1002/ijgo.12666

Bull JR, Rowland SP, Scherwitzl EB, Scherwitzl R, Danielsson KG, Harper J. Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles. NPJ Digit Med. 2019;2(1). http://dx.doi.org/10.1038/s41746-019-0152-7

Harlow, S. D. & Ephross, S. A. Epidemiology of Menstruation and Its Relevance to Women’s Health. Epidemiologic Reviews 17, 265–286 (1995).

Allotey J, Fernandez S, Bonet M, Stallings E, Yap M, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;m3320. http://dx.doi.org/10.1136/bmj.m3320

Khan SM, Shilen A, Heslin KM, Ishimwe P, Allen AM, Jacobs ET, et al. SARS-CoV-2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT study. Am J Obstet Gynecol. 2022;226(2):270–3. http://dx.doi.org/10.1016/j.ajog.2021.09.016

Li F, Lu H, Zhang Q, Li X, Wang T, Liu Q, et al. Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol. BMJ Open. 2021;11(2):e045524. http://dx.doi.org/10.1136/bmjopen-2020-045524

Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Mol Hum Reprod. 2020;26(6):367–73. http://dx.doi.org/10.1093/molehr/gaaa030

Morelli F, Meirelles LE de F, de Souza MVF, Mari NL, Mesquita CSS, Dartibale CB, et al. COVID-19 infection in the human reproductive tract of men and nonpregnant women. Am J Trop Med Hyg. 2021 http://dx.doi.org/10.4269/ajtmh.20-1098

Baena-García L, Aparicio VA. Author response to comment on: Premenstrual and menstrual changes reported after COVID-19 vaccination: The EVA project. Womens Health (Lond Engl). 2022;18:174550572211294. http://dx.doi.org/10.1177/17455057221129411

Bouchard TP, Schneider M, Schmidt M, Manhart M, Fehring RJ. Menstrual cycle parameters are not significantly different after COVID-19 vaccination. J Womens Health (Larchmt). 2022;31(8):1097–102. http://dx.doi.org/10.1089/jwh.2022.0097

Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021;42(1):260–7. http://dx.doi.org/10.1016/j.rbmo.2020.09.020

Gibson EA, Li H, Fruh V, Gabra M, Asokan G, Jukic AMZ, et al. Covid-19 vaccination and menstrual cycle length in the Apple Women’s Health Study. NPJ Digit Med. 2022;5(1). http://dx.doi.org/10.1038/s41746-022-00711-9

Mushtaq A, Arif S, Sabih F. Premenstrual symptoms as predictor of quality of life in reproductive-aged women of Rawalakot, Azad Kashmir: A cross sectional study. J Pak Med Assoc. 2020;1–12. http://dx.doi.org/10.47391/jpma.417

Jaiswal A, Madaan S, Talwar D, Kumar S, Acharya N, Acharya S, et al. Post-COVID-19 menstrual abnormalities and infertility: Repercussions of the pandemic. J Educ Health Promot. 2022;11(1):170. http://dx.doi.org/10.4103/jehp.jehp_1200_21

Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues. Fertil Steril. 2020;114(1):33–43. http://dx.doi.org/10.1016/j.fertnstert.2020.05.001

Darney BG, Boniface ER, Van Lamsweerde A, Han L, Matteson KA, Cameron S, et al. Impact of coronavirus disease 2019 (COVID‐19) vaccination on menstrual bleeding quantity: An observational cohort study. BJOG. 2023;130(7):803–12. http://dx.doi.org/10.1111/1471-0528.17471

Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re’em Y, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021;38(101019):101019. http://dx.doi.org/10.1016/j.eclinm.2021.101019

Chao MJ, Menon C, Elgendi M. Effect of COVID-19 vaccination on the menstrual cycle. Front Med (Lausanne). 2022;9. http://dx.doi.org/10.3389/fmed.2022.1065421




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