Angiotensin-Converting Enzyme Gene Polymorphism in Obesity and Its Interaction with Blood Pressure in Academicians
DOI:
https://doi.org/10.18196/mmjkk.v25i2.22867Keywords:
Angiotensin-converting enzyme (ACE) gene, Blood Pressure, ObesityAbstract
Obesity is one of the risk factors for hypertension. Obesity in hypertensive patients determines the severity of hypertension. Angiotensin-converting enzyme (ACE) is an enzyme that triggers vasoconstriction. ACE gene insertion/deletion polymorphisms may be associated with hypertension. This study aims to determine an association between ACE gene polymorphisms and blood pressure in obese patients. This research used an analytic observational study with a cross-sectional design. The research sample consisted of 36 obese academicians. Blood samples were taken from the patients to examine the ACE gene polymorphism. The correlative hypothesis used the Kruskal-Wallis test. The results showed that the most common types of ACE gene polymorphisms were type II (55.6%), type ID (33.3%), and type DD (11.1%)—the mean value of systolic blood pressure type II 123.29mmHg, type ID 125.82mmHg, DD 134.5mmHg. The mean value of diastolic pressure in ACE gene polymorphism type II was 81.57mmHg, type ID was 79.73mmHg, and type DD was 82.5mmHg. The Kruskal-Wallis test showed a relationship between ACE polymorphism and systolic pressure at p=0.705 (p>0.05) and the relationship between ACE polymorphism and diastolic pressure at p=0.980 (p>0.05). It concluded that there is no relationship between the ACE gene polymorphism and blood pressure in obese academicians.
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