The Correlation between Total Urine Protein Levels and The Frequency of Hemodialysis in Chronic Kidney Failure Patients
DOI:
https://doi.org/10.18196/mmjkk.v25i1.24138Keywords:
Chronic Kidney Failure, Hemodialysis, Proteinuria, Frequency of Hemodialysis, Quality of Life of PatientsAbstract
Chronic Kidney Failure (CKF) is a global health problem with a high prevalence, including in Indonesia. Renal replacement therapy, such as hemodialysis, is used to maintain the life of patients with CKF. The study aims to analyze the correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital from January to September 2023. The research is quantitative and descriptive, using cross-sectional survey methods and secondary data from patient medical records. Statistical analysis uses the Spearman test to test the correlation between variables. Total of HD frequency 1x/week = 6, 2x/week = 58, 3x/week= 1. In order, the trace of protein + 1 = 6, +2 = 58 , +3 = 1. The result of the analysis showed that the total urine protein rate with a frequency of hemodialysis was negatively correlated (r= 0,026; p= 0,84), also did not correlate with gender (r= -0,039; p= 0,756), comorbid (r= -0,038; p= 0,766), and age (r= 0,174; p= 0,166). The conclusion is that there is no correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital.
References
Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, et al. Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis. Remuzzi G, editor. PLoS ONE. 2016 Jul 6;11(7):e0158765.
Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2020 Feb;395(10225):709–33.
Hustrini NM, Susalit E, Rotmans JI. Prevalence and risk factors for chronic kidney disease in Indonesia: An analysis of the National Basic Health Survey 2018. J Glob Health. 2022 Oct 14;12:04074.
Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, et al. KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD. American Journal of Kidney Diseases. 2014 May;63(5):713–35.
Setiawan D, Harun H, Azmi S, Priyono D. Indikasi dan Persiapan Hemodialis Pada Penyakit Ginjal Kronis. JKA. 2018 Jul 29;7:113.
Putri TD, Mongan AE, Memah MF. Gambaran kadar albumin serum pada pasien penyakit ginjal kronik stadium 5 non dialisis. eBM [Internet]. 2016 Jan 27 [cited 2023 Sep 22];4(1). Available from: https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/10861
Setiawan D, Harun H, Azmi S, Priyono D. Biomarker Acute Kidney Injury (AKI) pada Sepsis. JKA. 2018 Jul 29;7:113.
Purqoti DN, Arifin Z, Fatmawati BR, Ilham I, Istianah I, Hapipah H. Upaya Pengenalan Faktor Risiko Dan Pencegahan Gagal Ginjal Kronis. losari. 2023 Jun 3;5(1):6–10.
Setiati S, Alwi I, Sudoyo AW. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Vol. 2. Jakarta: Internal Publishing; 2015.
Nakajima K, Higuchi R, Mizusawa K. Trace Proteinuria and the Incidence of Overt Proteinuria After Five Years: Results of the Kanagawa Investigation of the Total Checkup Data From the National Database-5 (KITCHEN-5). J Clin Med Res. 2020;12(9):618–23.
Fleming GM. Renal replacement therapy review: Past, present and future. Organogenesis. 2011 Jan;7(1):2–12.
Nissenson AR, Fine RE. Handbook of Dialysis Therapy. 6th ed. Elsevier; 2022. 944 p.
Faridah VN, Ghozali MS, Aris A, Sholikhah S, Ubudiyah M. Effect of Hemodialysis Adequacy on Quality of Life in Older adults with Chronic Kidney Disease. Indonesian J Community Health Nurs. 2021 Jul 5;6(1):28.
Salame C, Eaton S, Grimble G, Davenport A. Protein Losses and Urea Nitrogen Underestimate Total Nitrogen Losses in Peritoneal Dialysis and Hemodialysis Patients. Journal of Renal Nutrition. 2018 Sep;28(5):317–23.
Rolfes SR, Pinna K, Whitney E. Understanding Normal and Clinical Nutrition [Internet]. 8th ed. USA: Brooks Cole; 2008. Available from: https://razanmut.files.wordpress.com/2017/05/understanding-normal-and-clinical-nutrition-8th-edgnv64.pdf
Tomé D, Benoit S, Azzout-Marniche D. Protein metabolism and related body function: mechanistic approaches and health consequences. Proc Nutr Soc. 2021 May;80(2):243–51.
Brunner, Suddarth. Buku Ajar Keperawatan Medikal Bedah Edisi 12. 12th ed. Jakarta: EGC; 2015.
Insani AA, Ayu PR, Anggraini DI. Hubungan Lama Menjalani Hemodialisis Dengan Status Nutrisi Pada Pasien Penyakit Ginjal Kronik (PGK) Di Instalasi Hemodialisa RSUD Dr. H. Abdul Moeloek Provinsi Lampung. Jurnal Majority. 2019;8(1).
Zha Y, Qian Q. Protein Nutrition and Malnutrition in CKD and ESRD. Nutrients. 2017 Feb 27;9(3):208.
Indonesian Renal Registry [Internet]. 2018 p. 16–8. (11th Report Of Indonesian Renal Registry). Available from: https://www.indonesianrenalregistry.org/data/IRR%202018.pdf
Astrini WG, Hasibuan P, Irsan A. Hubungan Kadar Hemoglobin (Hb), Indeks Massa Tubuh (Imt) Dan Tekanan Darah Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Di Rsud Dokter Soedarso Pontianak Bulan April 2013. In 2018.
Pranandari R, Supadmi W. Faktor Risiko Gagal Ginjal Kronik Di Unit Hemodialisis Rsud Wates Kulon Progo. 2015;11(2).
Mallappallil M, Friedman EA, Delano BG, McFarlane SI, Salifu MO. Chronic kidney disease in the elderly: evaluation and management. Clinical Practice. 2014 Sep;11(5):525–35.
Kadir A. Hubungan Patofisiologi Hipertensi dan Hipertensi Renal. JIlmKedokt Wijaya Kusuma. 2018 Feb 13;5(1):15.
Muttaqin A, Sari K. Asuhan Keperawatan Gangguan Sistem Perkemihan. Jakarta: Salemba Medika; 2014.
Yonata A, Islamy N, Taruna A, Pura L. Factors Affecting Quality of Life in Hemodialysis Patients. IJGM. 2022 Sep;Volume 15:7173–8.
Rasyid H, Kasim H, Zatalia SR, Sampebuntu J. Quality of Life in Patients with Renal Failure Undergoing Hemodialysis. Acta Med Indones. 2022;54(2).
Sharma S, Smyth B. From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options. Kidney Blood Press Res. 2021;46(4):411–20.
Nuari NA, Widayati D. Gangguan Pada Sistem Perkemihan Dan Penatalaksanaan Keperawatan. Vol. 1. Yogyakarta: Deepublish; 2017. 274 p.
Chandra B, Haning S, Siokh Y, Bulan J, Adhy W. Prevalensi Proteinuria Dengan Pemeriksaan Dipstik Urin Pada Pasien Hipertensi Di Wilayah Kerja Puskesmas Daerah Terpencil Kabupaten Rote Ndao. 2020
Trimarchi H. Remnant Proteinuria in Chronic Hemodialysis. In: Suzuki H, editor. Hemodialysis [Internet]. InTech; 2013 [cited 2024 Jun 17]. Available from: http://www.intechopen.com/books/hemodialysis/remnant-proteinuria-in-chronic-hemodialysis
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