Analysis of Fungal Causes Onychomycosis and Its Risk Factors in Farmers at South Sulawesi, Indonesia

Authors

  • Bramantyas Kusuma Hapsari Department of Microbiology, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia
  • A. Nur Anna AS Department Nursing, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia
  • Andi Salsa Anggeraini Department of Microbiology, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia
  • Andi Rabi’atul Adawiah Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia
  • Zulkifli Zulkifli Department of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia

DOI:

https://doi.org/10.18196/mmjkk.v25i2.24759

Keywords:

fungi, risk factors, onychomycosis, nails

Abstract

Onychomycosis is a fungal infection of the nail caused by dermatophytes, non-dermatophyte, mould (NDM), and yeast. The purpose of the research is to determine the cause of onychomycosis and its risk factors in farmers' nails in Pacciro Village, South Sulawesi, Indonesia. This is an observational research, where macroscopically and microscopically examination used to determine the type of fungus, and questionnaire used to determine the risk factors. By using purposive sampling, there were 47 subjects of farmer with suspected of nails onychomycosis. Most of participants were middle aged and elderly (75%), and had medical history of both or one of hypertension and diabetes mellitus (72%). The result show that 31.08% have poor hygiene, and 27.03% have fairly good hygiene. There were only 14.86 % samples succesfully cultured and determined caused by non-dermatophyte fungi (Aspergillus sp). The Chi-Square test shows a correlation between extrinsic factors (environmental condition and personal hygiene) and Onychomycosis (p = 0.001). There were no correlation between type of fungi (p = 0.21), age (p = 0.30) and medical history (p = 0.44) with Onychomycosis. It concluded that Onychomycosis in study area is caused by Aspergillus sp, with the risk factors of environmental condition and personal hygiene.

References

Wahyuningsih R, Adawiyah R, Sjam R, Prihartono J, Wulandari EAT, Rozaliyani A, et al. Serious fungal disease incidence and prevalence in Indonesia. Mycoses. 2021;64(10):1203–12. Available from: https://doi.org/10.1111/myc.13304

Ayanlowo OO, Oladele RO. Fungal Nail Infections among Cassava Farmers and Processors in Southwest Nigeria. West Afr J Med. 2022;39(11):1127–33. Available from: https://pubmed.ncbi.nlm.nih.gov/36453258/

Bodman MA, Khan K. Onychomycosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441853/

Jawetz E, Melnick JL, Adelberg EA. Medical Microbiology. 26th ed. New York: McGraw-Hill; 2013. Available from: https://www.dcrustlms.in/upload/AA095-26-Medical%20Microbiology-%20Jawetz.pdf

Onychomycosis among Rural Farmers in a Southwestern Part of Nigeria. Egypt Dermatol Online J. 2011;7(1):Article 4. Available from: https://www.edoj.org.eg/vol007/0701/004/01.htm

Kayarkatte MN, Singal A, Pandhi D. Impact of onychomycosis on the quality of life: Dermatology Life Quality Index based cross sectional study. Skin Appendage Disord. 2020;6(2):105–11. Available from: https://karger.com/sad/article/6/2/115/291335

Tosti A. Nail Disorders. London: CRC Press; 2018. Available from: https://books.google.com/books/about/Nail_Disorders.html?id=IKJTDwAAQBAJ

Gupta AK, Sharma R. Recent advances in therapies for onychomycosis and its management. Curr Fungal Infect Rep. 2019;13(2):90–8. Available from: https://www.researchgate.net/publication/334023851

Leung AKC, Lam JM, Leong KF, Hon KL, Barankin B, Leung AAM, et al. Onychomycosis: An updated review. Recent Pat Inflamm Allergy Drug Discov. 2019;13(3):212–23. Available from: https://pubmed.ncbi.nlm.nih.gov/31738146/

Nurwulan D, Hidayatullah TA, Nuzula AF, Puspita R. Profil dermatofitosis superfisial periode Januari–Desember 2017 di Rumah Sakit Islam Aisiyah Malang. Saintika Med. 2019;1(2):40–5. Available from: https://ejournal.umm.ac.id/index.php/sainmed/article/view/8625

Lipner SR, Scher RK. Onychomycosis: Clinical overview and diagnosis. J Am Acad Dermatol. 2019;80(4):835–51.e3. Available from: https://www.sciencedirect.com/science/article/pii/S0190962218306666

Bitew A, Wolde S. Prevalence, risk factors, and spectrum of fungi in patients with onychomycosis in Addis Ababa, Ethiopia: A prospective study. J Trop Med. 2019;2019:1375279. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835839/

Maskan Bermudez N, Rodríguez-Tamez G, Perez S, Tosti A. Onychomycosis: Old and new. J Fungi. 2023;9(4):456. Available from: https://www.mdpi.com/2309-608X/9/4/456

Prevalence, Risk Factors, and Type of Organism in Fungal Foot Infection and Toenail Onychomycosis in Thai Diabetic Patients. J Med Assoc Thai. 2018;101(3):339–44. Available from: https://pubmed.ncbi.nlm.nih.gov/29900728/

Campbell CK, Johnson EM, Warnock DW. Identification of Pathogenic Fungi. Hoboken, NJ: Wiley; 2013. (Ch. 11–16). Available from: https://onlinelibrary.wiley.com/doi/epdf/10.1002/9781118520055.fmatter

Republik Indonesia. Perlindungan dan Pemberdayaan Petani. Jakarta: Pemerintah Indonesia; 2013. Available from: https://www.dpr.go.id/dokjdih/document/uu/UU_2013_19.pdf

Wahyuningsih S. Pemeriksaan jamur kuku (Onikomikosis) pada kuku pekerja sawah di Desa Candimulyo Jombang [thesis]. Jombang: STIKes Insan Cendekia Medika; 2015. Available from: https://repository.itskesicme.ac.id/id/eprint/4699/

Husen F, Ratnaningtyas NI, Aini N, Khasanah H, et al. Jamur non-dermatofita pada kuku jari tangan (finger nails) penyebab onikomikosis. J Bina Cipta Husada. 2023;19(1). Available from: https://sinelitabmas.unsoed.ac.id/google-doc/6479351.pdf

Tosti A. Nail Disorders. London: CRC Press; 2018. Available from: https://books.google.com/books/about/Nail_Disorders.html?id=IKJTDwAAQBAJ

Husen F, Ratnaningtyas NI, Aini N, Khasanah H, et al. Jamur non-dermatofita pada kuku jari tangan (finger nails) penyebab onikomikosis. J Bina Cipta Husada. 2023;19(1). Available from: https://sinelitabmas.unsoed.ac.id/google-doc/6479351.pdf

Earle K, Valero C, Conn DP, et al. Review: Pathogenicity and virulence of Aspergillus fumigatus. Virulence. 2023;14(1):1–25. Available from: https://www.tandfonline.com/doi/full/10.1080/21505594.2023.2175529

Khairina N, Alsaegh L, Rahayu T, Mujiati R. Identification of Non-Dermatophyte Fungi Causing Nail Onychomycosis (Tinea unguium) in Rice Farmers. J Media Analis Kesehatan. 2024. Available from: https://www.researchgate.net/publication/381886037

Frazier WT, Santiago-Delgado ZM, Stupka KC. Onychomycosis: Rapid Evidence Review. Am Fam Physician. 2021;104(4):359–67. Available from: https://www.aafp.org/pubs/afp/issues/2021/1000/p359.html

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Published

2025-07-31

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Research