Email this article 
Polymorphism of CYP1A1 (Ile462Val) Gene Related to Uterine Myoma in Malays Ethnicity of South Sumatera
Abstract
ABSTRACT
ASSOCIATION BETWEEN CYP1A1 (Ile462Val) GENE POLYMORPHISM AND OCCURANTE OF UTERINE MYOMA IN MALAYS POPULATION IN SOUTH SUMATERA.
Bella Ria Astuti1, Ferry Yusrizal2 dan Legiran3
Biomedical Science Program, Faculty of Medicine, University Sriwijaya
Background : Uterine myoma is a tumor in the myometrium. Uterine myoma is a disease associated with interactions between genes, hormones, growth factors, cytokines, and the environment. Myoma has never been found before menarche, whereas after menopause only about 10% of myomas still grow. In general the incidence of uterine myoma is predicted to reach 20-30% in women over 35 years. In Indonesia myoma was found 2.39% - 11.7%. Uterine myomas can cause various symptoms including menometroragia, pelvic pain, spontaneous abortion and infertility. that the growth and development of uterine myomas depends on estrogen. Cytochrome CYP450 system is a group of enzymes involved in biosynthesis of steroid hormones and metabolic activation of carcinogens. CYP1A1 is one of three members of the CYP1 family that plays a role in the metabolism of large numbers of xenobiotics. The purpose of this study is to analyze the relationship of CYP1A1 (Ile462Val) gene polymorphism with the incidence of uterine myoma in ethnic Malays in South Sumatra.
Methods : This study is an observational analytic study with a case control. This research was conducted in February 2019 in the laboratory of molecular Biology, Faculty of Medicine, Sriwijaya University. Test the statistics using the chi square test. The study sample used blood samples taken in 70 samples consisting of 35 case samples and 35 control cases. CYP1A1 (Ile462Val) gene polymorphism using the method PCR-RFLP.
Results : There is a relationship between Polymorphism between genotypes and gene alleles CYP1A1 (Ile462Val) with the incidence of uterine myoma in ethnic Malays in South Sumatra.
Key words : Polymorphism, Gene CYP1A1 (Ile462Val), Uterine leiomyoma.
Citations : 63 (2001-2015)
Keywords
Full Text:
PDFReferences
DAFTAR PUSTAKA
A.J. Gooszen, Koninklijk Instituut Voor Taal- Land en Volkenkude (Netherlands). A Demographic History Of The Indonesia Archipelago, 1880-1942, KITLV Press.1999.ISBN 90-6718-128-5, 9789067181280.
Anwar, Mochamad. 2011. Ilmu Kandungan, Ed. 3, Cet. 1. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo. 274.
Bailliere.2006. The Epidemiolgy of uterine Leiomyomas.12:169-176.
Bale,AE.2001. Buku Mutasi Gen CYP1A1 UGM. Yogyakarta
Britt,Findlay,2002, Yamaguchi Health Profile 2005. Jakarta : Ministry of Health S, Shinmura Y, et al. Suppressive Actvities of OGGI and Republic Of Indonesia ; 2007; hal 50-51.
Bazia A.2003.Endokrinologi Ginekologi. Jakarta : Media Aesculapies, pp : 151-157.
Baziad, Ali. 2002. Kontrasepsi Hormonal. Jakarta:Yayasan Bina Pustaka Sarwono Prawirohardjo
Boyapati,S.M.,Shu, X.O., Gao,Y.T.,Cai,Q.,Jin, F. & Zheng, W. (2005) Polimorphisms in CYP1A1 and breast carcinoma risk in a population based control study of Chinese Women. Cancer : Interdisciplinary International Journal of the American Cancer Society, 103,2228-2235.
Census, Figure Obtained Based On The Percentage Of Malays in 2000 census and the total Indonesian Population in 2010.
Champbel, N.A.Reece J.B. Mitchel, L.G. Biologi. Alih Bahasa Lestari, R, Safitri A
Simarmata L, Hardani. Jakarta : Erlangga. 2002.
Cheng-Hong Yang, Laeng, Yu-Huei Cheng, and Li-Yeh Chuang.2010. A Natural PCR-RFLP Primer Design for SNP. Proceeding of the International Multi Conference of Engineers and Computer Scientists Vol I. Hongkong.
Covaco I, Piedade R, Msellem MI, et al. Cytochrome 1AI and 1B1 gene diversity in the Zanzibar Island. Trop Med and Int Health.2012;17:854-7.
Derek Llewellyn-Jones. Fundamentals of Obstetry and Gynaecology. Edisi 6. Syney ; 1994
Djuwantono T. 2004. Terapi GnRH agonis sebelum histerektomi. Mioma: Farmacia 3:38- 41.
Edwards, D.R.V., Baird, D.D. & Hartmann, K.E. (2013). Association of age at menarche with increasing number of fibroids in a cohort of women who underwent standardized ultrasound assessment. American Journal of Epidemiology, 178(3): 426–433.
Feng Y, Lin X, Zhou S, Xu N, Yi T, Zhao X. asosiasi antara polimorfisme dari ER-gen dan
risiko oma rahim leiomy- (ULM). Tumor Biol 2013; 34 (5): 3077-82.
Ganong, William F. 2008. Buku Ajar Fisiologi Kedokteran Edisi 2. Jakarta: EGC
Guyton AC. 2002. Fisiologi Manusia. Jakarta: EGC.
Issa,I., J., Wu DS, Yang F, Zeng HY,Lei FM, Zhou WD,Li H, Tao P, (2006) Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer : a case control study., Zhonghua Liu Xing Bing Xue Za Zhi.
Hafafah, R. 2013. Definisi Metode Penelitian Case Control. [diakses15 Januari 2015].
Hall, J.E. & Guyton, A.C. (2011). Guyton and Hall Textbook of Medical Physiology. Philadelphia: Elsevier, p: 1086.
Haney A. 2000. Pengambilan keputusan klinis mengenai leiomyomata: apa yang kita butuhkan dalam milenium berikutnya. perspektif kesehatan lingkungan: 835-839.
Herr D, Bettendorf H, Denschlag D, Keck C, Pietrowski D. Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma. Arch Gynecol Obstet 2006; 274: 367-71.
https://id.wikipedia.org/wiki/Melayu_Palembang. Di akses tanggal 8-11-2018
Hsieh YY, Chang CC, Tsai FJ, Lin CC, Yeh LS, Peng CT. Androgen receptor trinucleotide polymorphism in leiomyoma. J Assist Reprod Genet 2004 ;21 : 453-7.
Issa., Li JY,Wu DS, Yang F, Zeng HY, Lei FM, Zhou WD, Li H, Tao P. Study on serum organochlorines pesticides (DDTs) level,CYP1A1 genetic polymorphism and risk of breast cancer : a case control study. Zhonghua Liu Xing Bing Xue Za Zhi 2006;217-22.
Lemeshow S, Lwanga, SK.1991.Sample Size Determination in Health Studies.WHO.
Lin CC, Yeh LS, Peng CT. 2004. Androgen Reseptor Trinucleotide Polimorfisme di Mioma. Jurnal Reproduksi dibantu dan Genetika 21, 453-457. : sturucture elucidation using electrochemistry, mass spectrometry and NMR. Drug Metab dispos.2009;37:571-9.
Jin H. Analisis hubungan antara COMT, CYP1A1 gen polimorfisme dan leiomyoma rahim. Universitas Jilin; 2008. [10] Barão MA, Oliveira E, Gomes MT, da Silva ID,
Johansson T, Jurva U, Gronberg G, et al. Novel metabolites of amodiaquine formed by CYPIA1 and CYP1B1 : structure elucidation using electrochemistry, mass spectrometry and NMR. Drug Metab dispos.2009.
Joedosapoetro MS. 2005. Ilmu Kandungan Edisi Kedua. Jakarta: Yayasan Bina Pustaka, pp: 38-41.
Khan AT, Shehmar M, Gupta JK. Uterine Fibroids : perspektif saat ini. Int J Womens Health 2014; 6: 95-114.
Lethaby A, Vollenhoven B. 2002.. 2002. Fibroid (myomatosis rahim, leiomioma). bukti klinis: 1666-1678.
Llewellyn-Jones Derek,. 2001. Dasardasar Obstetri dan Ginekologi Edisi 6. Jakarta: Hipokrates,
Makinen N, Vahteristo P, Kämpjärvi K, Arola J, Bützow R, Aaltonen LA. MED12 ekson 2
mutasi pada histopatologi leiomioma uterine. 2013; 21
Maruo T, Ohara N, Wang Je, Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Updat.2004;10;207-20.
Manuaba, I.A.C., Ida Bagus Gde Fajar Manuaba, Ida Bagus Gde Manuaba. 2010. Ilmu
Kebidanan, Penyakit Kandungan, dan KB Untuk Pendidikan Bidan, Ed. 2. Jakarta: EGC.556:601.
Manuaba B.G. 2003. Penuntun Kepaniteraan Klinik Obstetric dan Ginekologi Edisi Kedua. Jakarta: EGC, pp: 309-312.
Matsuo H. Peraturan steroid 2004. Sex pertumbuhan leiomyoma rahim dan apoptosis. Update reproduksi manusia 10, 207reproduksi manusia 10, 207 reproduksi manusia 10, 207220.
Marshall LM, Spiegelman D, Goldman MB. 1998. Sebuah studi prospektif faktor reproduksi dan penggunaan kontrasepsi oral dalam kaitannya dengan risiko leiomyoma rahim. 70: 432 – 439.
Mehine M, Makinen N, Heinonen HR, Aaltonen LA, Vahteristo P. Genomics dari rahim mas leiomyoma : wawasan dari tinggi-throughput sequencing. Fertil Steril 2014; 102: 621-9.
Michnovicz JJ, Rosenberg DW. Oxidative metabolism of estrogens in rat intestinal mitochon- dria. Biochem Pharmacol 1992; 43: 1847-52. [6] Sowers MR, Wilson AL, Kardia SR, Chu J, McConnell DS. CYP1A1 and CYP1B1 polymor- phisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal. Am J Med 2006; 119: S44-51.
Newton, C.R. and A. Graham. 1994. PCR. UK: Bios Scientific Publisher.
Nierth-Simpson EN, Martin MM, Chiang TC, Melnik LI, Rhodes LV, Muir SE, Burow ME, McLachlan JA. 2009. Manusia rahim otot LV, Muir SE, Burow ME, McLachlan JA. 2009. Manusia rahim otot polos dan Leiomioma sel berbeda dalam signaling 17βestradiol mereka cepat: implikasi untuk proliferasi. Endokrinologi 150, 2436-2445.
Nott et al,2008 MYH Proteins Against G :C to T:A Mutations Caused by 3. Castellsaque X and Munoz N. Chapter 3 : Cofactors in 8-hydroxyguanine. Journal 0f 2003;24(6) :1031-1037.
Orita, M,H Iwahana, H. Kanazawa, K Hayashi, dan T. Sekiya.1989. Detection of polymorphisms of human DNA by gel electrophoresis as a single-strand conformation polymorphism.Proc. Natl.Acad.Sci.86:2766-2770.
Parker WH. 2007. Etiology, syptomatology and diagnosis of uterin myomas. 87:725-733.
Parker, W.H. (2007). Etiology, symptomatology, and diagnosis of uterine myomas. Fertility and Sterility, 87(4), pp.725–736.
Parker, W.H. 2007. Etiology, Symptomatology and Di-agnosis of Uterine Myomas. California : Depar-tement of Obstetrics and and Gynecology UCLASchool of Medicine
Prawirohardjo, Sarwono. 2009. Ilmu Kandungan. Jakarta: Yayasan Bina Pustaka
Walker CL, Stewart EA. 2005. Fibroid Uterus: Walker CL, Stewart EA. 2005. Ilmu 308, 1589-1592.
Wiknjosastro, Abdul Bari Syapifudin, Trijatmo Rachimhadi (Ed). 2010. Ilmu Kandungan. Jakarta. PT Bina Pustaka Sarwono Prawiroharjo. 716 halaman.
Ryan GL, syrop CH, Van Voorhis BJ. Peran, demiology epi-, dan sejarah alam dari lesi massa uterine ute- jinak. Clin Obstet Gynecol 2005; 48: 312-24.
Salimi S, Khodamian M, Narooie-Nejad M, Hajizadeh A, Fazeli K, Namazi L, et al. Asosiasi
Polimorfisme dan Haplotype dalam sitokrom gen P450 1B1 dengan leiomioma uteri: Sebuah studi kasus kontrol. Biomed Rep 2015; 3 (2): 201-6.
Sartori MG, Girao MJ, Castro Rde A. Peran MSP saya CYP1A1 polimorfisme gen dalam lopment deve- fibroid rahim. Fertil Steril 2010; 94: 2783-5.
Sastroasmoro,Sudigdo,Sofyan I.1995. Dasar-Dasar Metodologi Penelitian Klinis. Bina Rupa Aksara. Jakarta.
Scott JR, Disala PJ, Hammond CB. 2002. Danforth Buku Saku Obstetric dan ginekologi. Jakarta: Widya Medika, pp: 484-487.
Sowers, M.R., Wilson, A. L., Kardia, S.R.,Chu, J. & Mcconnell, D.S. (2006) CYPIAI and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premnopausal and perimenopausal. The American journal of medicine.119,S44-S51.
Stiborová M, Martínek V, Rýdlová H, Koblas T, Hodek P. Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers. Cancer Lett 2005; 220: 145-54.
Swine,S(2009). Uterine fibroids. Emedicinehealth. http://www.emedicinehealth.com/uterine_ fibroids/article_em.htmFibroids%20overview--diakses April 2017.
Tri Kurniasari. 2010. Karakteristik Mioma Uteri di RSUD D.r Moeward Surakarta Periode Januari 2009-Januari 2010.
Thomason, Philip. 2008. Leiomyoma uterus (fibroid). http://emedicine.medscape com/article/405676-overview. Diakses tanggal 1 Maret 2018.Victory R, Romano W, Bennett J, Diamond M. 2006. Clinical Gynecology. Churchill Livingstone, Elsevier. p.179-205.
Wahyono, Daniel Djoko. Prinsip-prinsip Genetika Molekul dalam Analisis Genetika Terkini. At http://bio.unsoed.ac.id.
Wiknjosastro, Hanifa. 2009. Ilmu Kandungan, Ed. 2, Cet. 7. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo.338:334.
Wise, L.A., Laughlin-Tommaso, S.K., 2016. Epidemiology of Uterine Fibroids: From Menarche to Menopause. Clinical obstetrics and gynecology 59(1): 2-24
Wu J, Cheng Y (1995) [Research on the relationship between estrogen receptor, progesterone receptor, cell proliferation associated antigen in uterine leiomyoma and nuclear body density of myoma, serum reproductive hormone concentrations]. Zhonghua Fu Chan Ke Za Zhi 30(10):603–607
Wylie, Linda. 2010. Esensial Anatomi & Fisiologi Dalam Asuhan Maternitas, Ed. 2. Jakarta: EGC.195
Wiknjosastro H et al.,. 2005. Ilmu Kandungan Edisi Kedua. Jakarta: Yayasan Bina Pustaka, pp: 338-384.
Ye Y, Cheng X, Luo HB, Liu L, Li YB, Hou YP. CYP1A1 dan polimorfisme genetik CYP1B1 dan leiomyoma rahim risiko pada wanita Cina. J Membantu Reprod Genet 2008; 25: 389-94. [9]
DOI: https://doi.org/10.18196/mm.200249
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Editorial Office:
Journal Room, G1 (Biomedic) Building, Ground Floor, Faculty of Medicine and Health Science Universitas Muhammadiyah Yogyakarta,
Jalan Lingkar Selatan (Brawijaya), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta, Indonesia
Phone: +62 274 387 656 (ext: 231)
WA : +62 811-2650-303
Website: http://journal.umy.ac.id/index.php/mm
E-mail: mmjkk@umy.university
Mutiara Medika: Jurnal Kedokteran dan Kesehatan is licensed under a Creative Commons Attribution 4.0 International License. View My Stats