Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes

Alfun Dhiya An, Supriyatiningsih Supriyatiningsih

Abstract


Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression. This research aim to analyze differences in the level of Cyclin-D1 expression in ovarian endometriosis and ovarian carcinoma associated with the pathogenesis of endometrioma and ovarian carcinoma. Analytical observational study with cross sectional approach to cyclin-D1 expression between endometrioma and ovarian carcinoma with good and bad differentiation. The research subjects were 20 cases of endometrioma, each of the 20 cases of ovarian carcinoma were well and poorly differentiated. Statistical analysis using the ANOVA test on the level of cyclin-D1 expression between groups. The mean cyclin-D1 expression in endometrioma was 67.25. The mean of well-differentiated ovarian carcinoma was 132.41. The mean of poorly differentiated ovarian carcinoma was 128.83. Anova test resulted in a significant difference between the expression of cyclin-D1 endometrioma and ovarian carcinoma with good and bad differences (p = 0.00 <0.05). There is a significant difference between endometrioma and ovarian carcinoma with good and bad differentiation. Endometrioma cyclin-D1 expression was lower than ovarian carcinoma with good and bad differentiation.


Keywords


Endometrioma; ovarian carcinoma; cyclin-D1

Full Text:

PDF

References


Lahmuddin T. Korelasi Antara Overekspresi p53 dengan Derajat Histopatologi dan Stadium Klinis Karsinoma Karsinoma Ovarium. Jurnal Kedokteran dan Kesehatan, vol. 2, no.3. 2015.

Oepomo TD, Endometriosis: Patogenesis, Dampak Pada Kualitas Hidup, dan Penanggulangan, Surakarta: UNS Press, 2012.

Chiung-Ru Lai, Chih-Yi Hsu, Yi-Jen Chen, Ming-Shyen Yen, Kuan-Chong Chao, Anna Fen-Yau Li. Ovarian Cancers Arising from Endometriosis: A Microenvironmental Biomarker Study Including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2. Department of Pathology and Laboratory Medicine. Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Pathology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. 2013.

Nehzat F, Datta MS, Hanson V, Pejovic T, Nehzat C. The Relationship of Endometriosis and Ovarian Malignancy : A Review, Fertility Sterility Vol 90 No.5 November 2008. American Society for Reproducive Medicine. 2008. 1959-67.

Jacob TZ. Penanganan Endometriosis, ed I, Sagung Seto, Jakarta, 2009, p. 8

Sita D, Oepomo TD. Analisa Ekspresi Onkogen BCL-2 pada Endometrioma dan Karsinoma Ovarii. Tesis Program PPDS, Universitas Sebelas Maret. 2010. Surakarta.

Dewi R, Oepomo TD. Studi Perbedaan EkspresiProtein Retinoblastoma (pRb) antara Endometrioma Dan Karsinoma Ovarii, Tesis Program PPDS. 2011. Universitas Sebelas Maret, Surakarta

Ronny AN, Oepomo TD. Studi Perbedaan Ekspresi BAX antara Endometriosis Ovarii (Endometrioma) Dan Karsinoma Ovarii Serosum Berdifferensiasi Baik, Tesis Program PPDS. 2010. Universitas Sebelas Maret. Surakarta.

Nyoman T, Oepomo TD. Perbedaan Ekspresi C-MYC pada Endometriosis dan Karsinoma Ovarii. Tesis Program PPDS. 2011. Universitas Sebelas Maret Surakarta

Jumhur M, Oepomo TD. Studi Perbedaan Ekspresi COX-2 antara Endometrioma dan Karsinoma Ovarii. Tesis Program PPDS. 2011. Universitas Sebelas Maret, Surakarta.

Anggraeni A, Oepomo TD. Studi Perbedaan Ekspresi p53 Mutan antara Endometrioma dan Karsinoma Ovarii. Tesis Program PPDS. 2011. Universitas Sebelas Maret, Surakarta.

Puji H, Oepomo TD. Studi Perbedaan Ekspresi HER2/neu antara Endometrioma dan Karsinoma Ovarii. Tesis Program PPDS. 2011. Universitas Sebelas Maret, Surakarta

Edy P, Oepomo TD. Studi Perbedaan Ekspresi p27 antara Endometrioma dan Karsinoma Ovarii. Tesis Program PPDS. 2011. Universitas Sebelas Maret Surakarta

Etsu Tashiro, Ayako Tsuchiya and Masaya Imoto. Functions of Cyclin D1 as an Oncogene and Regulationof Cyclin D1 Expression Department of Biosciences and Informatics. Faculty of Science and Technology, Keio University. 2007. Yokohama. p. 223-8522, Japan (Received December 25, 2006/Accepted January 24, 2007/Online publication March 11, 2007).

Andrijono, 2004, Sinopsis Kanker Ginekologi, Divisi Onkologi Departemen Obstetri dan Ginekologi Fakultas Kedokteran Indonesia RSPUN dr. Cipto Mangunkusumo, Jakarta.

Kira H Bramswig, Marina Poettler, Matthias Unseld. Tumor Angiogenesis Soluble Carcinoembryonic Antigen Activates Endothelial Cells and Tumor Angiogenesis. Clinical Division of Oncology, Department of Medicine I and Comprehensive Cancer Center, Institute of Clinical Pathology, Department of Vascular Biology and Thrombosis Research, Centre for Bio-Molecular Medicine and Pharmacology, Medical University of Vienna. Vienna, Austria, and Tumor Immunology Laboratory. LIFE-Center, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich. 2013. Germany

Richard O. Burney MD, and Linda C, Giudice MD. Pathogenesis and Pathophysiology of Endometriosis. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Madigan Healthcare System, Tacoma, Washington and Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California. 2012.




DOI: https://doi.org/10.18196/mmjkk.v21i1.7212

Article Metrics

Abstract view : 38 times
PDF - 17 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Mutiara Medika: Jurnal Kedokteran dan Kesehatan


     

Editorial Office:
Journal Room, G1 (Biomedic) Building, Ground Floor, Faculty of Medicine and Health Science Universitas Muhammadiyah Yogyakarta, 
Jalan Lingkar Selatan (Brawijaya), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta, Indonesia
Phone: +62 274 387 656 (ext: 231)
WA : +62 882 3323 4696
Website: http://journal.umy.ac.id/index.php/mm 
E-mail: mmjkk@umy.university

Creative Commons License
Mutiara Medika: Jurnal Kedokteran dan Kesehatan is licensed under a Creative Commons Attribution 4.0 International License. View My Stats