Pengaruh Ekstrak Buah Anggur Merah (Vitis vinifera L) terhadap Kadar Trigliserida Darah Tikus Putih ( Rattus novergicuss )

Authors

  • Salmah Orbayinah Departemen Biokimia, Fakultas Kedokteran, Universitas Muhammadiyah Yogyakarta
  • Kurnia Eka Permana Departemen Biokimia, Fakultas Kedokteran, Universitas Muhammadiyah Yogyakarta

DOI:

https://doi.org/10.18196/mmjkk.v11i3.987

Keywords:

ekstrak buah anggur, Trigliserida, Rattus norvegicus

Abstract

AbstrakBuah anggur memiliki kandungan proanthosianidin dan resveratrol yang berkaitan erat dengan pencegahan hiperlipidemia khususnya hipertrigliserida. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah anggur merah (Vitis viniferra L.) terhadap kadar trigliserida darah tikus putih (Rattus norvegicus). Ekstrak anggur merah dibuat dalam berbagai dosis. Dosis I (100mg/200g BB/hari), dosis II(250mg/200g BB/2ml), dan dosis III (500mg/200g BB/hari). Pemberian ekstrak anggur merah dilakukan selama 10 hari. Hasil yang diperoleh menunjukkan bahwa terdapat perbedaan kadar trigliserida yang signifikan sebelum dan sesudah perlakuan pada masing masing kelompok nilai (p<0,05). Pada uji statistik menggunakan one way Anova menunjukkan nilai p=0,000 (p<0,05). Dosis Uji I mengalami penurunan sebesar 32,80 ± 7,99 ml/dL, dosis Uji II yaitu 60,74 ± 2,15 ml/dL, Uji III yaitu 69,41±3,87ml/dL sehingga terdapat perbedaan kadar trigliserida darah tikus putih antar kelompok yang signifikan. Disimpulkan bahwa pemberian ekstrak anggur merah berpengaruh terhadap penurunan kadar trigliserida darah tikus putih secara bermakna

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Published

2016-01-29

Issue

Vol. 11 No. 3 (2011)

Section

Research

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