The Effectiveness Of Tofu Liquid Waste As A Natural Phytoestrogen For Mandibular Bone Of Ovariectomized Rats
DOI:
https://doi.org/10.18196/di.v1i1.508Keywords:
Menopause, Periodontitis, Isoflavones, Tofu Liquid WasteAbstract
Estrogen is a steroid compound that has many benefits for the body's physiology.Hypoestrogenic women could have periodontitis in their mouth. Hormone
replacement therapy (HRT) is a therapy that used to reduce the disturbance caused
by estrogen deficiency. However, HRT has many side effects. Theoretical study
shows that isoflavones in tofu liquid waste has an element of a steroid compound.
The purpose of this study was to prove the effectiveness of isoflavones in the tofu
liquid waste by examining the microscopic structure, estrogen receptor expression
and MDA levels in rat mandibular bone post-ovariectomy. This research method
use a true experimental laboratory with randomized post test control group design.
Twenty-four female wistar rats were divided randomly into six groups, consisted
of a group of normal rat that does’nt ovariectomized (C1), 4 weeks
ovariectomized rats (C2), 8 weeks ovariectomized rats (C3) but no tofu liquid
waste was given, and 8 weeks ovariectomized rats that given tofu liquid waste at
the end of the 4th week of ovariectomy with three different doses (C4 = 1.2, C5 =
6; C6 = 12 ml / kg). Histopathological slide used to see the changes resulted in a
number of osteoclasts, osteocytes, periodontal ligament width, alveolar bone
height, the amount of estrogen receptor expression and MDA levels. The results
of statistical tests show that there is a difference in the rats between six different
groups (ANOVA, p <0.05) and there is a close relationship between the dose of
the tofu liquid waste with all parameter. The conclusion of this study is tofu
liquid waste could improve the microscopic structure, estrogen receptor
expression and MDA levels in rat mandibular bone post-ovariectomy.
Downloads
Published
2012-01-15
Issue
Section
Articles
License
License
Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva (IDJ) is licensed under an Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially. This license is acceptable for Free Cultural Works.
The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Copyright
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under an Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
