SP Transcription Family Involve In Tooth Development ?
DOI:
https://doi.org/10.18196/di.v1i1.520Keywords:
SP family, transcription factor, tooth developmentAbstract
Specificity Protein (SP) family members are tissue specific transcription factors.They regulate a wide range of cellular function including cells growth, apoptosis,
differentiation and tumor formation. This family composed of more than 25
member proteins, which contain a DNA-binding domain very well conserve
between all members with three tandem zinc fingers of the C2H2 type in their
Cterminal region. Recently, it has reported in mammalian genome, there are nine
Sp genes (Sp1-Sp9). Some previous study reported Sp3 knockout mice have
enamel/dentin layer defect. Sp4 mRNA express in E13- E16 of WT mouse incisor.
Sp7 mRNA express in at 15, 17 days of post coitum and P1 (postnatal day 1). Sp6
has another name epiprofin, I also worked with this genes. Sp6 mRNA expressed
in early stage of tooth development to the secretory stage of ameloblast. It also
reported Sp6 weakly expressed in mesenchymal odontoblast of the incisor. Sp6
deficient mice reported delay tooth development. SP family members play an
important role in tooth development.
Downloads
Published
2012-01-15
Issue
Section
Articles
License
License
Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva (IDJ) is licensed under an Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially. This license is acceptable for Free Cultural Works.
The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Copyright
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under an Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
