Pengaruh Stressor Renjatan Listrik (Electrical Foot Shock) Terhadap Kadar Serum Alkalin Fosfatase Tikus Wistar (Rattus Norvegicus) Jantan

Authors

  • Agustin Wulan Suci Dharmayanti Universitas Jember
  • Farizan Zata Hadyan Universitas Jember
  • Rudi Budirahardjo Universitas Jember

DOI:

https://doi.org/10.18196/di.v2i1.553

Keywords:

stressor renjatan listrik, hormon estrogen, hormon androgen, alkalin fosfatase

Abstract

Stres merupakan mekanisme kompensasi tubuh guna mempertahankan homeostasis walaupun dapat menyebabkan gangguan kesehatan. Hal ini disebabkan pada saat stres terjadi perubahan hormonal, terutama kortisol. Hormon kortisol dapat mempengaruhi kadar hormon estrogen atau androgen dimana kedua hormon tersebut berperan penting dalam proses metabolisme tulang. Pada metabolisme tulang, enzim alkalin fosfatase sangat dibutuhkan untuk pembentukan tulang. Tujuan penelitian ini adalah untuk mengetahui pengaruh stressor renjatan
listrik pada kadar serum alkalin fosfatase tikus wistar jantan. Penelitian ini merupakan eksperimental laboratoris dengan rancangan penelitian the post test only control group design. Penelitian ini dibagi menjadi dua kelompok yaitu kelompok kontrol dan kelompok perlakuan yang diberi perlakuan berupa stresor rasa sakit renjatan listrik dengan mengalirkan arus listrik 5-30mA, tegangan 25V dan frekuensi 60Hz selama 14 hari. Hasil penelitian menunjukkan bahwa rata-rata kadar serum alkalin fosfatase pada kelompok perlakuan lebih rendah dibanding kelompok kontrol. Hasil uji analisis Mann Whitney U menunjukan bahwa terdapat perbedaan yang bermaknaantara kelompok kontrol dan perlakuan (p<0.05). Kesimpulan menunjukkan bahwa stresor renjatan listrik dapat mempengaruhi proses pembentukan tulang yang ditandai dengan penurunan kadar alkalin fosfatase.

Author Biographies

Agustin Wulan Suci Dharmayanti, Universitas Jember

Biomedical Department, Dentistry Faculty, Jember University

Farizan Zata Hadyan, Universitas Jember

Pedodonsia Department, Dentistry Faculty, Jember University

Rudi Budirahardjo, Universitas Jember

Pedodonsia Department, Dentistry Faculty, Jember University

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Published

2013-01-16

Issue

Vol. 2 No. 1 (2013)

Section

Articles

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