The Expression Of Heat Shock Protein (Hsp) 25 At Compression And Tension Area DuringAlveolar Bone Remodeling

Muhammad Nurul Amin

Abstract


The activation of orthodontic appliance will generate mechanical force. This force
is used to depress tooth and the tissues surrounding it then stimulates alveolar
bone remodeling. Alveolar bone remodeling is divided into compression and
tension area. This stress becomes a signal to activate heat shock response
yielding heat shock protein (HSP) synthesis, especiallyhsp25isessential
foralveolarboneremodelingprocessitself. The aim of this study was to compare
hsp25 expression in compression and tension areas. This study using guinea pigs
mandibular first insicivus that given a mechanical force to see hsp25 expression
in both areas. The HSP25 expressionwas measured by counting this protein after
being conducted by immunohystochemistry method. It is analysed statistically
with one way Anova with level of significant p = 0,05.

Keywords


Heat shock protein (HSP)25; compression area; tension area; alveolar bone remodeling

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DOI: https://doi.org/10.18196/di.v1i1.518

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